Intelence and Diphen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Intelence (etravirine) and Diphen (diphenhydramine hydrochloride). Common drug interactions include bone density decreased among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Intelence and Diphen. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Intelence?

Intelence has active ingredients of etravirine. It is often used in hiv infection. eHealthMe is studying from 3,797 Intelence users. Check the latest studies of Intelence.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

On Jul, 24, 2026

19 people who take Intelence and Diphen together, and have interactions are studied.

What are the common drug interactions of Intelence and Diphen, by gender? *:

female:

Bone density decreased
Chronic kidney disease
Emotional distress
Pain
Tooth loss
Fibula fracture
Maternal exposure during pregnancy (use of substance during pregnancy)
Vision blurred
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Ankle fracture

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Depression
Osteopenia (a condition where bone mineral density is lower than normal)
Quality of life decreased
Tooth loss
Asthenia (weakness)
Blindness
Blood creatinine increased
Hypokinesia (decreased bodily movement)

What are the common drug interactions of Intelence and Diphen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Maternal exposure during pregnancy (use of substance during pregnancy)
Vision blurred

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Bone disorder
Chronic kidney disease
Decreased activity
Osteonecrosis (death of bone)
Quality of life decreased
Bone density decreased

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Asthenia (weakness)
Bone cyst
Bone density decreased
Cerebral haemorrhage (bleeding within the brain)
Chronic kidney disease
Depression
Emotional distress
Mobility decreased (ability to move is reduced)

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Tooth loss
Asthenia (weakness)
Fibula fracture
Ankle fracture
Blindness
Blood creatinine increased
Death

60+:

Blood pressure increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drooling (drop saliva uncontrollably from the mouth)
Dysphagia (a condition in which swallowing is difficult or painful)
Paralysis
Speech disorder
Tongue disorder (disease of tongue)

What are the existing conditions these people have? *

Hiv Infection: 17 people, 89.47%
Pain: 7 people, 36.84%
Hypersensitivity: 6 people, 31.58%
High Blood Cholesterol: 6 people, 31.58%
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 5 people, 26.32%
Depression: 5 people, 26.32%
Asthma: 4 people, 21.05%
Bacterial Infection: 4 people, 21.05%
Gastric Disorder (disease of stomach): 4 people, 21.05%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 15.79%

* Approximation only. Some reports may have incomplete information.

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