Invanz and Zide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Invanz (ertapenem sodium) and Zide (hydrochlorothiazide). Common drug interactions include infusion related reaction among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Invanz and Zide. It is created by eHealthMe based on reports of 83 people who take the same drugs from the FDA, and is updated regularly.

What is Invanz?

Invanz has active ingredients of ertapenem sodium. It is often used in urinary tract infection. eHealthMe is studying from 3,961 Invanz users. Check the latest studies of Invanz.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

On Aug, 11, 2026

83 people who take Invanz and Zide together, and have interactions are studied.

What are the common drug interactions of Invanz and Zide, by gender? *:

female:

Infusion related reaction
Weight decreased
Abdominal pain
Anaemia (lack of blood)
Colitis (inflammation of colon)
Colitis ulcerative (inflammation of colon with ulcer)
Constipation
Erythema (redness of the skin)
Female genital tract fistula (passage in genital tract of female)
Frequent bowel movements

male:

Dehydration (dryness resulting from the removal of water)
Acute prerenal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
Abscess (pus)
Abscess limb (limb infection)
Agitation (state of anxiety or nervous excitement)
Blood sodium decreased
Cellulitis (infection under the skin)
Coagulation time prolonged
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Confusional state

What are the common drug interactions of Invanz and Zide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anal abscess
Abscess (pus)
Abscess limb (limb infection)
Cellulitis (infection under the skin)
Gangrene (body tissue dies)
Perirectal abscess
Sepsis (a severe blood infection that can lead to organ failure and death)
Soft tissue necrosis (death of soft tissue)
Subcutaneous abscess
Depression

40-49:

Dizziness
Drug hypersensitivity
Dysarthria (speech disorder)
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)
Lethargy (tiredness)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Sensation of heaviness

50-59:

Depression
Diarrhoea
Drug ineffective
Dysgeusia (disorder of the sense of taste)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hyperhidrosis (abnormally increased sweating)
Insomnia (sleeplessness)
International normalised ratio increased

60+:

Dyspepsia (indigestion)
Malaise (a feeling of general discomfort or uneasiness)
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Weight decreased
Abdominal pain
Anaemia (lack of blood)
Colitis (inflammation of colon)
Colitis ulcerative (inflammation of colon with ulcer)
Constipation
Erythema (redness of the skin)

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 33 people, 39.76%
Allergies: 25 people, 30.12%
Pain: 6 people, 7.23%
Sepsis (a severe blood infection that can lead to organ failure and death): 5 people, 6.02%

* Approximation only. Some reports may have incomplete information.

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