Invega and Diphen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Invega (paliperidone) and Diphen (diphenhydramine hydrochloride). Common drug interactions include spinal cord compression among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Invega and Diphen. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Invega?

Invega has active ingredients of paliperidone. It is often used in bipolar disorder. eHealthMe is studying from 32,353 Invega users. Check the latest studies of Invega.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

On Jul, 29, 2026

32 people who take Invega and Diphen together, and have interactions are studied.

What are the common drug interactions of Invega and Diphen, by gender? *:

female:

Spinal cord compression
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Upper respiratory tract infection
Urticaria (rash of round, red welts on the skin that itch intensely)
Chills (felling of cold)
Chest discomfort
Migraine (headache)
Rash
Hypoaesthesia (reduced sense of touch or sensation)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

male:

Dizziness
Tremor (trembling or shaking movements in one or more parts of your body)
Diarrhoea
Disturbance in attention
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dyspnoea (difficult or laboured respiration)
Eating disorder
Fibromyalgia (a long-term condition which causes pain all over the body)
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)

What are the common drug interactions of Invega and Diphen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Dizziness
Oedema (fluid collection in tissue)
Oedema peripheral (superficial swelling)

40-49:

Chronic kidney disease
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Psychotic disorder
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)

50-59:

n/a

60+:

Blood pressure decreased
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Migraine (headache)
Productive cough
Pruritus (severe itching of the skin)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Rash
Sinusitis (inflammation of sinus)
Sputum discoloured
Swelling

What are the existing conditions these people have? *

High Blood Pressure: 5 people, 15.62%
Sleep Disorder: 4 people, 12.50%
Immunodeficiency Common Variable: 4 people, 12.50%
Agitation (state of anxiety or nervous excitement): 4 people, 12.50%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 9.38%
Jock Itch (fungal infection of the groin and upper thighs): 3 people, 9.38%
Irritability: 3 people, 9.38%
Hair Loss: 3 people, 9.38%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 9.38%
Depression: 3 people, 9.38%

* Approximation only. Some reports may have incomplete information.

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