Invega and Reglan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Invega (paliperidone) and Reglan (metoclopramide hydrochloride). Common drug interactions include pleural effusion among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Invega and Reglan. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Invega?

Invega has active ingredients of paliperidone. It is often used in bipolar disorder. eHealthMe is studying from 32,353 Invega users. Check the latest studies of Invega.

What is Reglan?

Reglan has active ingredients of metoclopramide hydrochloride. It is often used in gastroparesis. eHealthMe is studying from 29,455 Reglan users. Check the latest studies of Reglan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

31 people who take Invega and Reglan together, and have interactions are studied.

What are the common drug interactions of Invega and Reglan, by gender? *:

female:

Pleural effusion (water on the lungs)
Pneumonia
Renal failure chronic (long lasting kidney dysfunction)
Road traffic accident
Sinus bradycardia (an unusually slow heartbeat due to heart disease)
Spinal column stenosis (narrowing of spinal column)
Spinal osteoarthritis (joint cartilage loss in spine)
Tenosynovitis stenosans (a common disorder characterized by catching, snapping or locking of the involved finger flexor tendon, associated with dysfunction and pain)
Thrombocytopenia (decrease of platelets in blood)
Tooth loss

male:

Arthralgia (joint pain)
Compulsive shopping
Asthma
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic kidney disease
Deafness
Dehydration (dryness resulting from the removal of water)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drooling (drop saliva uncontrollably from the mouth)
Feeling cold

What are the common drug interactions of Invega and Reglan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abasia (inability to walk)
Agitation (state of anxiety or nervous excitement)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drooling (drop saliva uncontrollably from the mouth)
Hemiplegia (paralysis of one side of the body)
Speech disorder
Tardive dyskinesia (a disorder that involves involuntary movements)
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting
Weight decreased

30-39:

Fall
Nerve injury
Arthralgia (joint pain)
Compulsive shopping
Eating disorder
Hospitalisation
Nephrolithiasis (calculi in the kidneys)
Spondylolisthesis (displacement of a vertebra or the vertebral column in relation to the vertebrae below)
Weight increased
Spinal disorder (disease of spine a back bone)

40-49:

Osteomyelitis (infection of bone)
Osteonecrosis of jaw (death of bone of jaw)
Osteoporosis (bones weak and more likely to break)
Pain
Pathological fracture (broken bone caused by disease)
Pelvic pain
Phaeochromocytoma (vascular tumour of the adrenal gland)
Pleural effusion (water on the lungs)
Pneumonia
Renal failure chronic (long lasting kidney dysfunction)

50-59:

Anxiety
Depression
Dysuria (painful or difficult urination)
Fatigue (feeling of tiredness)
Hunger
Merycism (a rare disease in which food is chewed, swallowed, and then returned to the mouth and chewed again)
Muscle spasms (muscle contraction)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Periodic limb movement disorder

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 16 people, 51.61%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 15 people, 48.39%
Stress And Anxiety: 8 people, 25.81%
Pain: 8 people, 25.81%
Depression: 7 people, 22.58%
High Blood Cholesterol: 7 people, 22.58%
Nausea (feeling of having an urge to vomit): 6 people, 19.35%
Diabetes: 5 people, 16.13%
Hypersensitivity: 5 people, 16.13%
Sleep Disorder: 4 people, 12.90%

* Approximation only. Some reports may have incomplete information.

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