Invokamet and Losartan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Invokamet (canagliflozin; metformin hydrochloride) and Losartan (losartan potassium). Common drug interactions include blood potassium decreased among females and glycosylated haemoglobin increased among males.

The phase IV clinical study analyzes what interactions people have when they take Invokamet and Losartan. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Invokamet?

Invokamet has active ingredients of canagliflozin; metformin hydrochloride. eHealthMe is studying from 1,965 Invokamet users. Check the latest studies of Invokamet.

What is Losartan?

Losartan has active ingredients of losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 177,692 Losartan users. Check the latest studies of Losartan.

On Aug, 12, 2026

74 people who take Invokamet and Losartan together, and have interactions are studied.

Invokamet and Losartan drug interactions.

What are the common drug interactions of Invokamet and Losartan, by gender? *:

female:

Blood potassium decreased
Blood potassium increased
Blood urine present
Cardiac arrest
Cellulitis (infection under the skin)
Chest discomfort
Cold sweat
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Creatinine renal clearance increased

male:

Glycosylated haemoglobin increased
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Adverse event
Affect lability (emotional incontinence)
Agitation (state of anxiety or nervous excitement)
Neck pain
Palpitations (feelings or sensations that your heart is pounding or racing)
Road traffic accident
Skin disorder (skin disease)

What are the common drug interactions of Invokamet and Losartan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood calcium increased
Glycosylated haemoglobin increased

40-49:

Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Adverse event
Affect lability (emotional incontinence)
Agitation (state of anxiety or nervous excitement)
Bacterial prostatitis (bacterial infection of the prostate gland)
Fungal infection
Papillary thyroid cancer
Urinary tract infection

50-59:

Chronic kidney disease
Cough
Creatinine renal clearance increased
Diarrhoea
Dyspareunia (painful sexual intercourse)
Glycosylated haemoglobin increased
Haematuria (presence of blood in urine)
Hyperhidrosis (abnormally increased sweating)
Hyperkalaemia (damage to or disease of the kidney)
Hypermagnesaemia (an electrolyte disturbance in which there is an abnormally elevated level of magnesium in the blood)

60+:

Fall
Injection site nodule (small swelling or aggregation of cells in the body, esp. an abnormal one at injection site)
Pulmonary congestion (congestion in the lungs)
Abasia (inability to walk)
Abdominal discomfort
Abdominal pain
Alopecia (absence of hair from areas of the body)
Asthma
Blood creatinine increased
Blood potassium decreased

What are the existing conditions these people have? *

Diabetes: 21 people, 28.38%
Type 2 Diabetes: 20 people, 27.03%
High Blood Cholesterol: 13 people, 17.57%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 16.22%
Cushing's Syndrome (obesity, a rounded face, increased fat): 11 people, 14.86%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 10.81%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 9.46%
Pain: 6 people, 8.11%
Rickets (softening of bones): 5 people, 6.76%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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