Isentress and Codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Isentress (raltegravir potassium) and Codeine (codeine sulfate). Common drug interactions include anhedonia among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Isentress and Codeine. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Isentress?

Isentress has active ingredients of raltegravir potassium. It is often used in hiv infection. eHealthMe is studying from 16,529 Isentress users. Check the latest studies of Isentress.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

On Jul, 11, 2026

22 people who take Isentress and Codeine together, and have interactions are studied.

Isentress and Codeine drug interactions.

What are the common drug interactions of Isentress and Codeine, by gender? *:

female:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Osteopenia (a condition where bone mineral density is lower than normal)
Renal impairment (severely reduced kidney function)
Ankle fracture
Arthralgia (joint pain)
Asthenia (weakness)
Blood pressure fluctuation
Bone loss

male:

Emotional distress
Osteoporosis (bones weak and more likely to break)
Spinal compression fracture (fracture due to spinal compression on bone)
Anaemia (lack of blood)
Ankle fracture
Arthralgia (joint pain)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Depression
Hand fracture
Multiple fractures

What are the common drug interactions of Isentress and Codeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Emotional distress
Osteoporosis (bones weak and more likely to break)
Hand fracture
Anaemia (lack of blood)
Chronic kidney disease
Mobility decreased (ability to move is reduced)
Osteopenia (a condition where bone mineral density is lower than normal)

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Decreased activity
Emotional distress
Quality of life decreased
Spinal compression fracture (fracture due to spinal compression on bone)
Arthralgia (joint pain)
Bone density decreased
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Depression

60+:

Emotional distress
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone loss
Chronic kidney disease
Decreased appetite
Insomnia (sleeplessness)
Mobility decreased (ability to move is reduced)
Nausea (feeling of having an urge to vomit)
Syncope (loss of consciousness with an inability to maintain postural tone)
Bone density decreased

What are the existing conditions these people have? *

Bacterial Infection: 7 people, 31.82%
High Blood Pressure: 7 people, 31.82%
Stress And Anxiety: 5 people, 22.73%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 22.73%
Depression: 5 people, 22.73%
Viral Infection: 3 people, 13.64%
Inflammation: 3 people, 13.64%
Diabetes: 3 people, 13.64%
Urinary Retention (the inability to completely or partially empty the bladder): 3 people, 13.64%
Indigestion: 3 people, 13.64%

* Approximation only. Some reports may have incomplete information.

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