Isordil and Avapro drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Isordil (isosorbide dinitrate) and Avapro (irbesartan). Common drug interactions include dizziness among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Isordil and Avapro. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Isordil?

Isordil has active ingredients of isosorbide dinitrate. eHealthMe is studying from 3,022 Isordil users. Check the latest studies of Isordil.

What is Avapro?

Avapro has active ingredients of irbesartan. It is often used in high blood pressure. eHealthMe is studying from 19,840 Avapro users. Check the latest studies of Avapro.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

27 people who take Isordil and Avapro together, and have interactions are studied.

What are the common drug interactions of Isordil and Avapro, by gender? *:

female:

Dizziness
Dizziness postural
Drug ineffective
Duodenal ulcer haemorrhage (bleeding duodenal ulcer)
Dyslipidaemia (abnormal amount of lipids)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Dyspnoea paroxysmal nocturnal (respiratory distress that awakens patients from sleep)
Electrocardiogram st segment elevation
Electrocardiogram st-t change

male:

Anxiety
Emotional distress
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Anaemia (lack of blood)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood glucose increased
Cardiac index decreased
Chest discomfort
Chronic kidney disease

What are the common drug interactions of Isordil and Avapro, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Renal failure (kidney dysfunction)
Anxiety
Emotional distress
Injury
Pain
Chronic kidney disease
Death
Nephropathy (damage to or disease of a kidney)
Renal impairment (severely reduced kidney function)
Stress

50-59:

Coronary artery stenosis (narrowing of coronary artery)
Cough
Decreased appetite
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diarrhoea
Disability
Dyslipidaemia (abnormal amount of lipids)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Dyspnoea paroxysmal nocturnal (respiratory distress that awakens patients from sleep)

60+:

Serum ferritin increased
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Atrioventricular block first degree (heart block first degree)
Blood glucose increased
Cardiac failure congestive
Cardiac index decreased
Chest discomfort
Confusional state
Cyanosis peripheral (blue tint in fingers or extremities, due to inadequate circulation)
Delirium (wild excitement)

What are the existing conditions these people have? *

Diabetes: 3 people, 11.11%
High Blood Cholesterol: 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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