Isordil and Phoslo drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Isordil (isosorbide dinitrate) and Phoslo (calcium acetate). Common drug interactions include vomiting among females and nephrogenic systemic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Isordil and Phoslo. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Isordil?

Isordil has active ingredients of isosorbide dinitrate. eHealthMe is studying from 3,022 Isordil users. Check the latest studies of Isordil.

What is Phoslo?

Phoslo has active ingredients of calcium acetate. eHealthMe is studying from 4,291 Phoslo users. Check the latest studies of Phoslo.

On Jul, 07, 2026

48 people who take Isordil and Phoslo together, and have interactions are studied.

What are the common drug interactions of Isordil and Phoslo, by gender? *:

female:

Vomiting
Anaemia (lack of blood)
Bacteraemia (presence of bacteria in the blood)
Cellulitis (infection under the skin)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Headache (pain in head)
Hyperkalaemia (damage to or disease of the kidney)
Hypoaesthesia (reduced sense of touch or sensation)
Activities of daily living impaired
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

male:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Anxiety
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bradycardia (abnormally slow heart action)
Cerebral atrophy (decrement in size of brain)
Coma (state of unconsciousness lasting more than six hours)
Dysarthria (speech disorder)
Emotional distress
Erythema (redness of the skin)
Fatigue (feeling of tiredness)

What are the common drug interactions of Isordil and Phoslo, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abortion spontaneous (naturally occurring miscarriage)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)

30-39:

n/a

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Depression
Disability
Fear
Injury
Multi-organ failure (multisystem organ failure)
Pain
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

50-59:

Pain
Pain of skin
Scar
Skin exfoliation (removal of the oldest dead skin cells)
Vomiting
Bacteraemia (presence of bacteria in the blood)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)

60+:

Pneumonia
Cardiac failure congestive
Hyperkalaemia (damage to or disease of the kidney)
Renal failure acute (rapid kidney dysfunction)
Renal failure acute on chronic (rapid or long lasting kidney failure)
Serum ferritin increased
Agitation (state of anxiety or nervous excitement)
Cardiac arrest
Cerebral atrophy (decrement in size of brain)
Confusional state

What are the existing conditions these people have? *

High Blood Pressure: 13 people, 27.08%
Diabetes: 11 people, 22.92%
Nuclear Magnetic Resonance Imaging Brain: 9 people, 18.75%
Anaemia (lack of blood): 8 people, 16.67%
Sleep Disorder: 5 people, 10.42%
Pain: 5 people, 10.42%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 10.42%
Chest Pain: 5 people, 10.42%
Pulmonary Embolism (blockage of the main artery of the lung): 3 people, 6.25%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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