Isosorbide dinitrate and Acetylcysteine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Isosorbide dinitrate (isosorbide dinitrate) and Acetylcysteine (acetylcysteine). Common drug interactions include emphysema among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Isosorbide dinitrate and Acetylcysteine. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Isosorbide dinitrate?

Isosorbide dinitrate has active ingredients of isosorbide dinitrate. It is often used in angina. eHealthMe is studying from 13,180 Isosorbide dinitrate users. Check the latest studies of Isosorbide dinitrate.

What is Acetylcysteine?

Acetylcysteine has active ingredients of acetylcysteine. It is often used in cough. eHealthMe is studying from 11,563 Acetylcysteine users. Check the latest studies of Acetylcysteine.

On Jul, 11, 2026

62 people who take Isosorbide dinitrate and Acetylcysteine together, and have interactions are studied.

Isosorbide dinitrate and Acetylcysteine drug interactions.

What are the common drug interactions of Isosorbide Dinitrate and Acetylcysteine, by gender? *:

female:

Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Pulmonary oedema (fluid accumulation in the lungs)
Haemoglobin decreased
Blood urea increased
Abnormal faeces (abnormal stool)
Acute respiratory failure
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic disorder
Arthralgia (joint pain)
Basophil count increased

male:

Pyrexia (fever)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Anxiety
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Cardiomegaly (increased size of heart than normal)
Chronic obstructive airways disease
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Epidermal necrolysis (skin condition that is usually caused by a reaction to drugs)
Fatigue (feeling of tiredness)
Fear

What are the common drug interactions of Isosorbide Dinitrate and Acetylcysteine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Cardiomegaly (increased size of heart than normal)
Cataract (clouding of the lens inside the eye)
Diabetic retinopathy (damage to the retina caused by complications of diabetes)
Gamma-glutamyltransferase increased
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Mitral valve incompetence (inefficient heart valve)
Pleural effusion (water on the lungs)
Pneumonia
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Pulmonary hypertension (increase in blood pressure in the lung artery)

60+:

Pneumonia
Urinary tract infection
Pulmonary oedema (fluid accumulation in the lungs)
Haemoglobin decreased
Blood urea increased
Sepsis (a severe blood infection that can lead to organ failure and death)
Abnormal faeces (abnormal stool)
Arthralgia (joint pain)
Oedema peripheral (superficial swelling)
Spinal osteoarthritis (joint cartilage loss in spine)

What are the existing conditions these people have? *

High Blood Pressure: 18 people, 29.03%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 14 people, 22.58%
Pain: 12 people, 19.35%
Hypokalemia (low potassium): 11 people, 17.74%
Anaesthesia: 10 people, 16.13%
Sedation: 9 people, 14.52%
Oedema (fluid collection in tissue): 9 people, 14.52%
Blood Potassium Decreased: 9 people, 14.52%
Cardiac Failure: 9 people, 14.52%
Urination - Excessive Volume: 8 people, 12.90%

* Approximation only. Some reports may have incomplete information.

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