Isosorbide dinitrate and Chantix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Isosorbide dinitrate (isosorbide dinitrate) and Chantix (varenicline tartrate). Common drug interactions include blood potassium decreased among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Isosorbide dinitrate and Chantix. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Isosorbide dinitrate?

Isosorbide dinitrate has active ingredients of isosorbide dinitrate. It is often used in angina. eHealthMe is studying from 13,180 Isosorbide dinitrate users. Check the latest studies of Isosorbide dinitrate.

What is Chantix?

Chantix has active ingredients of varenicline tartrate. It is often used in quit smoking. eHealthMe is studying from 89,889 Chantix users. Check the latest studies of Chantix.

On Jul, 20, 2026

61 people who take Isosorbide dinitrate and Chantix together, and have interactions are studied.

Isosorbide dinitrate and Chantix drug interactions.

What are the common drug interactions of Isosorbide Dinitrate and Chantix, by gender? *:

female:

Blood potassium decreased
Blood urea decreased
Crepitations (noises are produced by the rubbing of parts one against the other)
Fibrin d dimer increased
Fluid overload (too much fluid in the blood)
Foaming at mouth (excess saliva secretion)
Haemoglobin decreased
Hepatic cyst
Hypochloraemia (electrolyte disturbance in which there is an abnormally low level of the chloride ion in the blood)
Hypoglycaemic coma (coma due to deficiency of glucose in the bloodstream)

male:

Depression
Dyspnoea (difficult or laboured respiration)
Skin exfoliation (removal of the oldest dead skin cells)
Abdominal distension
Constipation
Anxiety
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive
Cardiomegaly (increased size of heart than normal)
Cataract (clouding of the lens inside the eye)

What are the common drug interactions of Isosorbide Dinitrate and Chantix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anxiety
Depression
Overdose
Suicide attempt

50-59:

Breast enlargement
Nipple pain
Weight decreased
Anaemia (lack of blood)
Blood triglycerides increased
Cardiac murmur (an heart sound in valve abnormality)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Depressed mood
Ill-defined disorder
Muscle atrophy (a decrease in the mass of the muscle)

60+:

Depression
Chronic kidney disease
Crepitations (noises are produced by the rubbing of parts one against the other)
Fibrin d dimer increased
Fluid overload (too much fluid in the blood)
Foaming at mouth (excess saliva secretion)
Haemoglobin decreased
Hepatic cyst
Hypochloraemia (electrolyte disturbance in which there is an abnormally low level of the chloride ion in the blood)
Hypoglycaemic coma (coma due to deficiency of glucose in the bloodstream)

What are the existing conditions these people have? *

Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 9 people, 14.75%
High Blood Pressure: 9 people, 14.75%
Depression: 7 people, 11.48%
High Blood Cholesterol: 7 people, 11.48%
Sleep Disorder: 6 people, 9.84%
Stress And Anxiety: 6 people, 9.84%
Asthma: 5 people, 8.20%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 5 people, 8.20%
Restless Leg Syndrome (a powerful urge to move your legs): 5 people, 8.20%
Cardiac Disorder: 5 people, 8.20%

* Approximation only. Some reports may have incomplete information.

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