Isosorbide dinitrate and Linzess drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Isosorbide dinitrate (isosorbide dinitrate) and Linzess (linaclotide). Common drug interactions include gastrooesophageal reflux disease among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Isosorbide dinitrate and Linzess. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Isosorbide dinitrate?

Isosorbide dinitrate has active ingredients of isosorbide dinitrate. It is often used in angina. eHealthMe is studying from 13,180 Isosorbide dinitrate users. Check the latest studies of Isosorbide dinitrate.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

On Jul, 04, 2026

39 people who take Isosorbide dinitrate and Linzess together, and have interactions are studied.

Isosorbide dinitrate and Linzess drug interactions.

What are the common drug interactions of Isosorbide Dinitrate and Linzess, by gender? *:

female:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Hospitalisation
Hypersomnia (excessive daytime sleepiness (eds))
Hypoaesthesia (reduced sense of touch or sensation)
Injection site haemorrhage (bleeding from injection site)
Ligament sprain (ligament stretched)
Lumbar vertebral fracture
Lung disorder (lung disease)
Lymphadenopathy (disease or enlargement of lymph nodes)

male:

Cardiac failure congestive
Dyspnoea (difficult or laboured respiration)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)
Depressed level of consciousness
Diarrhoea
Dysuria (painful or difficult urination)
Epistaxis (bleed from the nose)
Erythema (redness of the skin)
Haemoglobin decreased

What are the common drug interactions of Isosorbide Dinitrate and Linzess, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Contusion (a type of hematoma of tissue in which capillaries)
Fatigue (feeling of tiredness)
Injection site haemorrhage (bleeding from injection site)

40-49:

Dizziness

50-59:

Blood creatinine increased
Chronic kidney disease
Generalised oedema (swelling all over the body)
Nephrogenic anaemia (anaemia due to kidney disease)
Oedema peripheral (superficial swelling)
Renal disorder (kidney disease)
Renal failure (kidney dysfunction)

60+:

Nausea (feeling of having an urge to vomit)
Dyspnoea (difficult or laboured respiration)
Intracranial aneurysm (bulging, weak area in the wall of a cranial artery)
Anaemia (lack of blood)
Bone cancer metastatic
Cancer pain
Cardiac failure congestive
Cystitis (inflammation of the wall of the bladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 28.21%
Immunodeficiency Common Variable: 4 people, 10.26%
Stable Angina (a constant chest pain): 3 people, 7.69%
Immunodeficiency: 3 people, 7.69%
Urinary Tract Infection: 2 people, 5.13%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 5.13%
Primary Myelofibrosis (primary disorder of the bone marrow): 2 people, 5.13%
Pain: 2 people, 5.13%
Nausea (feeling of having an urge to vomit): 2 people, 5.13%
Muscle Aches (muscle pain): 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

Do you take Isosorbide dinitrate and Linzess?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously