Isosorbide dinitrate and Pletal drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Isosorbide dinitrate (isosorbide dinitrate) and Pletal (cilostazol). Common drug interactions include excessive eye blinking among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Isosorbide dinitrate and Pletal. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Isosorbide dinitrate?

Isosorbide dinitrate has active ingredients of isosorbide dinitrate. It is often used in angina. eHealthMe is studying from 13,180 Isosorbide dinitrate users. Check the latest studies of Isosorbide dinitrate.

What is Pletal?

Pletal has active ingredients of cilostazol. It is often used in blockage of leg arteries. eHealthMe is studying from 6,341 Pletal users. Check the latest studies of Pletal.

On Jul, 31, 2026

49 people who take Isosorbide dinitrate and Pletal together, and have interactions are studied.

Isosorbide dinitrate and Pletal drug interactions.

What are the common drug interactions of Isosorbide Dinitrate and Pletal, by gender? *:

female:

Excessive eye blinking (excessive blinking is dry eyes)
Feeling drunk
Frustration (a form of poorly expressed anger)
Gastric antral vascular ectasia (blood vessels in the lining of the stomach become fragile and become prone to rupture and bleeding)
Gastric haemorrhage (bleeding stomach)
Gastric mucosal lesion (lesion of stomach mucous membrane)
Gastric perforation (hole in stomach)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Granulocyte count decreased
Haematemesis (vomiting of blood)

male:

Pneumonia
Decreased appetite
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac failure congestive
Diarrhoea
Dysgeusia (disorder of the sense of taste)
Electrocardiogram qt prolonged
Eosinophil percentage increased
Fatigue (feeling of tiredness)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

What are the common drug interactions of Isosorbide Dinitrate and Pletal, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Peripheral swelling
Pruritus (severe itching of the skin)
Pulmonary embolism (blockage of the main artery of the lung)

60+:

Pneumonia
Decreased appetite
White blood cell count decreased
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Acute myocardial infarction (acute heart attack)
Anaemia (lack of blood)
Aphonia (inability to produce voice)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac failure congestive
Dehydration (dryness resulting from the removal of water)

What are the existing conditions these people have? *

High Blood Pressure: 6 people, 12.24%
Stable Angina (a constant chest pain): 5 people, 10.20%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 5 people, 10.20%
Reflux Oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus): 4 people, 8.16%
Renal Cell Carcinoma (a kidney cancer): 3 people, 6.12%
Multiple Drug Overdose Intentional: 3 people, 6.12%
Insomnia (sleeplessness): 3 people, 6.12%
Diarrhea: 3 people, 6.12%
Diabetes: 3 people, 6.12%
Depression: 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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