Isosorbide mononitrate and Dyazide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Isosorbide mononitrate (isosorbide mononitrate) and Dyazide (hydrochlorothiazide; triamterene). Common drug interactions include atrial fibrillation among females and fluid intake reduced among males.

The phase IV clinical study analyzes what interactions people have when they take Isosorbide mononitrate and Dyazide. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Isosorbide mononitrate?

Isosorbide mononitrate has active ingredients of isosorbide mononitrate. It is often used in angina. eHealthMe is studying from 26,858 Isosorbide mononitrate users. Check the latest studies of Isosorbide mononitrate.

What is Dyazide?

Dyazide has active ingredients of hydrochlorothiazide; triamterene. It is often used in high blood pressure. eHealthMe is studying from 11,506 Dyazide users. Check the latest studies of Dyazide.

On Jul, 12, 2026

24 people who take Isosorbide mononitrate and Dyazide together, and have interactions are studied.

Isosorbide mononitrate and Dyazide drug interactions.

What are the common drug interactions of Isosorbide Mononitrate and Dyazide, by gender? *:

female:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Aphasia (damage to the parts of the brain that control language)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Hemiplegia (paralysis of one side of the body)
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Feeding disorder (when children refuse to eat certain food groups)
Loss of consciousness
Vomiting
Eating disorder
Abnormal behaviour

male:

Fluid intake reduced
Nausea (feeling of having an urge to vomit)
Pleural effusion (water on the lungs)
Respiratory failure (inadequate gas exchange by the respiratory system)
Blood creatinine increased
General physical health deterioration (weak health status)
Sepsis (a severe blood infection that can lead to organ failure and death)
Ascites (accumulation of fluid in the abdominal cavity)
Blastomycosis (fungal infection caused by fungus blastomyces dermatitidis)
Blood pressure decreased

What are the common drug interactions of Isosorbide Mononitrate and Dyazide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Palpitations (feelings or sensations that your heart is pounding or racing)

50-59:

Fluid intake reduced
Nausea (feeling of having an urge to vomit)
Rash
Renal impairment (severely reduced kidney function)
Respiratory failure (inadequate gas exchange by the respiratory system)
Vomiting
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Constipation
Dehydration (dryness resulting from the removal of water)
Dysentery (infection of the intestines resulting in severe diarrhoea with the presence of blood and mucus in the faeces)

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Aphasia (damage to the parts of the brain that control language)
Blood pressure decreased
Cardiac failure congestive
Cardiac flutter (abnormal heart rhythm)
Chest pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Drug hypersensitivity
Drug ineffective
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Cardiac Disorder: 6 people, 25.00%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 6 people, 25.00%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 5 people, 20.83%
Wheezing (a high-pitched whistling sound made while you breath): 4 people, 16.67%
Urinary Tract Infection: 4 people, 16.67%
Chest Pain: 4 people, 16.67%
Depression: 4 people, 16.67%
Essential Hypertension (primary hypertension): 4 people, 16.67%
Heart Attack: 4 people, 16.67%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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