Isosorbide mononitrate and Midazolam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Isosorbide mononitrate (isosorbide mononitrate) and Midazolam (midazolam). Common drug interactions include chronic kidney disease among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Isosorbide mononitrate and Midazolam. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Isosorbide mononitrate?

Isosorbide mononitrate has active ingredients of isosorbide mononitrate. It is often used in angina. eHealthMe is studying from 26,858 Isosorbide mononitrate users. Check the latest studies of Isosorbide mononitrate.

What is Midazolam?

Midazolam has active ingredients of midazolam. eHealthMe is studying from 11,246 Midazolam users. Check the latest studies of Midazolam.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 19, 2026

27 people who take Isosorbide mononitrate and Midazolam together, and have interactions are studied.

Isosorbide mononitrate and Midazolam drug interactions.

What are the common drug interactions of Isosorbide Mononitrate and Midazolam, by gender? *:

female:

Chronic kidney disease
Diarrhoea
Renal failure (kidney dysfunction)
Vomiting
Anaemia (lack of blood)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Infusion related reaction
Nephrogenic anaemia (anaemia due to kidney disease)

male:

Renal failure (kidney dysfunction)
Cholecystitis acute (rapid infection of gallbladder)
Dementia (madness)
Depression
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperkalaemia (damage to or disease of the kidney)
Renal injury (kidney injury)
Renal tubular acidosis (medical condition that involves an accumulation of acid in the body due to a failure of the kidneys)
Renal tubular necrosis (death of kidney tubules)

What are the common drug interactions of Isosorbide Mononitrate and Midazolam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Maternal exposure during pregnancy (use of substance during pregnancy)
Angioplasty
Cellulitis (infection under the skin)
Dactylitis (dactylitis or sausage digit is inflammation of an entire digit (a finger or toe), and can be painful)
Lower respiratory tract infection
Malaise (a feeling of general discomfort or uneasiness)
Norovirus test positive
Osteomyelitis (infection of bone)
Pain
Pneumonia

30-39:

n/a

40-49:

Cholecystitis acute (rapid infection of gallbladder)
Pulmonary alveolar haemorrhage (acute bleeding)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Chronic kidney disease
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Septic shock (shock due to blood infection)

50-59:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Death
Hyperkalaemia (damage to or disease of the kidney)
Renal tubular acidosis (medical condition that involves an accumulation of acid in the body due to a failure of the kidneys)
Renal tubular necrosis (death of kidney tubules)

60+:

Diarrhoea
Renal failure (kidney dysfunction)
Abscess limb (limb infection)
Cholecystitis acute (rapid infection of gallbladder)
Cholecystitis infective (infection of gallbladder capable to infect other organs)
Nephrogenic anaemia (anaemia due to kidney disease)
Perineal abscess
Perirectal abscess
Renal tubular necrosis (death of kidney tubules)
Urinary tract infection

What are the existing conditions these people have? *

High Blood Pressure: 11 people, 40.74%
Stress And Anxiety: 9 people, 33.33%
Constipation: 8 people, 29.63%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 29.63%
Depression: 7 people, 25.93%
High Blood Cholesterol: 5 people, 18.52%
Type 2 Diabetes: 5 people, 18.52%
Pain: 4 people, 14.81%
Nausea (feeling of having an urge to vomit): 4 people, 14.81%
Diffuse Large B-Cell Lymphoma Stage Iv (cancer of b cells, a type of white blood cell-stage iv): 4 people, 14.81%

* Approximation only. Some reports may have incomplete information.

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