Istodax and Bactrim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Istodax (romidepsin) and Bactrim (sulfamethoxazole; trimethoprim). Common drug interactions include thrombocytopenia among females and cardiac failure among males.

The phase IV clinical study analyzes what interactions people have when they take Istodax and Bactrim. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Istodax?

Istodax has active ingredients of romidepsin. eHealthMe is studying from 1,054 Istodax users. Check the latest studies of Istodax.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

On Aug, 09, 2026

49 people who take Istodax and Bactrim together, and have interactions are studied.

What are the common drug interactions of Istodax and Bactrim, by gender? *:

female:

Thrombocytopenia (decrease of platelets in blood)
Bone marrow failure
Hepatic failure (liver failure)
Anaemia (lack of blood)
Pyoderma gangrenosum (ulcerating condition of skin that results in heaped borders with a typical appearance)
Ulcer
Haematotoxicity (toxins that destroy red blood cells)
Neutropenia (an abnormally low number of neutrophils)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Platelet disorder

male:

Cardiac failure
Thrombocytopenia (decrease of platelets in blood)
Melaena (the passage of black, tarry stools)
Neutropenia (an abnormally low number of neutrophils)
Skin ulcer
Cerebral haemorrhage (bleeding within the brain)
Dyspnoea (difficult or laboured respiration)
Hodgkin's disease (cancer originating from white blood cells)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hypotension (abnormally low blood pressure)

What are the common drug interactions of Istodax and Bactrim, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Hodgkin's disease (cancer originating from white blood cells)
Non-hodgkin's lymphoma (malignant (cancer) cells form in the lymph system)
Blood bilirubin increased
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)

40-49:

Electrocardiogram qt prolonged
Angioimmunoblastic t-cell lymphoma (mature t-cell cancer of the blood or lymph vessel)

50-59:

Bone marrow failure
Thrombocytopenia (decrease of platelets in blood)
Hepatic failure (liver failure)
Cerebral haemorrhage (bleeding within the brain)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hypotension (abnormally low blood pressure)
Multiple myeloma (cancer of the plasma cells)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Platelet disorder
Pyrexia (fever)

60+:

Thrombocytopenia (decrease of platelets in blood)
Cardiac failure
Cardiac arrest
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Klebsiella sepsis (klebsiella causes a potentially fatal whole-body inflammation)
Tumour invasion (starting of tumour)
Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
Melaena (the passage of black, tarry stools)
Skin ulcer
General physical health deterioration (weak health status)

What are the existing conditions these people have? *

T-Cell Lymphoma (a blood cell cancer): 13 people, 26.53%
Peripheral T-Cell Lymphoma Unspecified (peripheral t-cell cancer unspecified): 10 people, 20.41%
Angioimmunoblastic T-Cell Lymphoma (mature t-cell cancer of the blood or lymph vessel): 8 people, 16.33%
Lymphoma (cancer that begins in immune system cells): 7 people, 14.29%
Stress And Anxiety: 5 people, 10.20%
Pain: 5 people, 10.20%
Depression: 5 people, 10.20%
Neuropathy Peripheral (surface nerve damage): 4 people, 8.16%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 8.16%
High Blood Pressure: 4 people, 8.16%

* Approximation only. Some reports may have incomplete information.

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