Ivermectin and Valacyclovir drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ivermectin (ivermectin) and Valacyclovir (valacyclovir hydrochloride). Common drug interactions include drug ineffective among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Ivermectin and Valacyclovir. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Ivermectin?

Ivermectin has active ingredients of ivermectin. eHealthMe is studying from 2,199 Ivermectin users. Check the latest studies of Ivermectin.

What is Valacyclovir?

Valacyclovir has active ingredients of valacyclovir hydrochloride. It is often used in genital herpes. eHealthMe is studying from 42,108 Valacyclovir users. Check the latest studies of Valacyclovir.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

53 people who take Ivermectin and Valacyclovir together, and have interactions are studied.

Ivermectin and Valacyclovir drug interactions.

What are the common drug interactions of Ivermectin and Valacyclovir, by gender? *:

female:

Drug ineffective
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Skin exfoliation (removal of the oldest dead skin cells)
Pain
Breast cancer stage i
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Nausea (feeling of having an urge to vomit)
Rash
Arthritis (form of joint disorder that involves inflammation of one or more joints)

male:

Emotional distress
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Candida pneumonia (infection of lung by candida)
Cerebral disorder (brain disease)
Fatigue (feeling of tiredness)
Glomerulosclerosis (a hardening of the glomerulus in the kidney)
Hypertension (high blood pressure)
Mobility decreased (ability to move is reduced)
Plasma cell myeloma (cancer that begins in plasma cells)
Renal impairment (severely reduced kidney function)

What are the common drug interactions of Ivermectin and Valacyclovir, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Fatigue (feeling of tiredness)
Glomerulosclerosis (a hardening of the glomerulus in the kidney)
Hypertension (high blood pressure)
Immune system disorder
Mobility decreased (ability to move is reduced)
Pain
Renal impairment (severely reduced kidney function)

30-39:

Rash
Blindness transient (sudden loss of vision)
Blood bilirubin increased
Bone disorder
Cardiac murmur (an heart sound in valve abnormality)
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Disability
Discomfort
Drug ineffective
Hypersensitivity

40-49:

Abscess limb (limb infection)
Anal abscess
Cellulitis (infection under the skin)
Cellulitis of male external genital organ (infection of male genitals soft tissue)
Cellulitis staphylococcal (a type of bacteria originated skin soft tissue infection)
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Emotional distress
Gangrene (body tissue dies)
Genital abscess (build up of pus in genital)
Groin abscess (pus in groin)

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Emotional distress
Pain
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Osteopenia (a condition where bone mineral density is lower than normal)

60+:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Breast cancer stage i
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Confusional state
Constipation
Dry skin
Hepatic fibrosis (scarring process that represents the liver's response to injury)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Skin fissures (a crack in the skin)
Candida pneumonia (infection of lung by candida)

What are the existing conditions these people have? *

Hepatitis B Virus Test Positive: 10 people, 18.87%
Cytokine Release Syndrome (immediate complication occurring with the use of anti-t cell antibody infusions): 10 people, 18.87%
Angiocentric Lymphoma (extra nodal natural killer cell cancer): 10 people, 18.87%
Asthma: 8 people, 15.09%
Multiple Myeloma (cancer of the plasma cells): 6 people, 11.32%
Hiv Infection: 5 people, 9.43%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 5 people, 9.43%
Pain: 3 people, 5.66%
Inflammation: 3 people, 5.66%
High Blood Pressure: 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

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