Janumet and Avonex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Janumet (metformin hydrochloride; sitagliptin phosphate) and Avonex (interferon beta 1a). Common drug interactions include joint stiffness among females and bone cancer metastatic among males.

The phase IV clinical study analyzes what interactions people have when they take Janumet and Avonex. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Janumet?

Janumet has active ingredients of metformin hydrochloride; sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 25,023 Janumet users. Check the latest studies of Janumet.

What is Avonex?

Avonex has active ingredients of interferon beta 1a. It is often used in multiple sclerosis. eHealthMe is studying from 198,544 Avonex users. Check the latest studies of Avonex.

On Jul, 28, 2026

43 people who take Janumet and Avonex together, and have interactions are studied.

What are the common drug interactions of Janumet and Avonex, by gender? *:

female:

Joint stiffness
Lactose intolerance (inability to digest lactose)
Metastases to liver (cancer spreads to liver)
Muscle spasms (muscle contraction)
Muscular weakness (muscle weakness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nephrolithiasis (calculi in the kidneys)
Oedema (fluid collection in tissue)
Oesophageal dilatation (enlarged oesophagus)
Oesophageal stenosis (narrowing of oesophagus)

male:

Bone cancer metastatic
Drug ineffective
Obesity (having too much body fat)
Pneumonia
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Diarrhoea
Fracture
Gait disturbance
Hypersensitivity
Respiratory tract infection

What are the common drug interactions of Janumet and Avonex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Blood triglycerides increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Diabetic nephropathy (diabetic kidney disease)
Hypertension (high blood pressure)
Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Obesity (having too much body fat)
Abasia (inability to walk)

50-59:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Hepatic steatosis (fatty liver disease)
Hypersensitivity
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Urinary retention (the inability to completely or partially empty the bladder)
Varicella
Asthma
Hypertension (high blood pressure)

60+:

Adverse event
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diarrhoea
Fall
Fracture
Gait disturbance
Hypersensitivity
Muscular weakness (muscle weakness)
Oedema (fluid collection in tissue)
Respiratory tract infection

What are the existing conditions these people have? *

Pain: 6 people, 13.95%
Gait Disturbance: 6 people, 13.95%
Wheezing (a high-pitched whistling sound made while you breath): 4 people, 9.30%

* Approximation only. Some reports may have incomplete information.

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