Janumet and Catapres drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Janumet (metformin hydrochloride; sitagliptin phosphate) and Catapres (clonidine hydrochloride). Common drug interactions include mitral valve incompetence among females and amylase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Janumet and Catapres. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Janumet?

Janumet has active ingredients of metformin hydrochloride; sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 25,023 Janumet users. Check the latest studies of Janumet.

What is Catapres?

Catapres has active ingredients of clonidine hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 6,680 Catapres users. Check the latest studies of Catapres.

On Jul, 12, 2026

31 people who take Janumet and Catapres together, and have interactions are studied.

What are the common drug interactions of Janumet and Catapres, by gender? *:

female:

Mitral valve incompetence (inefficient heart valve)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Nephrocalcinosis (a condition in which calcium levels in the kidneys are increased)
Oropharyngeal pain
Pancreatic mass
Panniculitis (inflammation of the subcutaneous fat)
Personality disorder
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Pneumonia
Pulmonary hypertension (increase in blood pressure in the lung artery)

male:

Amylase increased
Chronic kidney disease
Burning sensation
Choking sensation (feeling of obstruction in respiratory system)
Contusion (a type of hematoma of tissue in which capillaries)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Cough
Diabetic nephropathy (diabetic kidney disease)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Fall

What are the common drug interactions of Janumet and Catapres, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Cardiac failure congestive
Chronic kidney disease
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Diabetic nephropathy (diabetic kidney disease)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Hypertensive heart disease
Nephropathy (damage to or disease of a kidney)
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)

40-49:

Spinal disorder (disease of spine a back bone)

50-59:

Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Mitral valve calcification (calcium deposit in mitral valve)
Mitral valve incompetence (inefficient heart valve)
Nephrocalcinosis (a condition in which calcium levels in the kidneys are increased)
Neuropathy peripheral (surface nerve damage)
Oropharyngeal pain
Palpitations (feelings or sensations that your heart is pounding or racing)
Pancreatitis (inflammation of pancreas)
Panniculitis (inflammation of the subcutaneous fat)
Personality disorder

60+:

Amylase increased
Lipase increased
Burning sensation
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Choking sensation (feeling of obstruction in respiratory system)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic kidney disease
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Dehydration (dryness resulting from the removal of water)

What are the existing conditions these people have? *

Type 2 Diabetes: 5 people, 16.13%
Pain: 4 people, 12.90%
Peripheral Neuropathy (damage to nerves of the peripheral nervous system): 3 people, 9.68%
Neuralgia (pain in one or more nerves): 3 people, 9.68%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 9.68%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 6.45%
Pain In Extremity: 2 people, 6.45%
Neuropathy Peripheral (surface nerve damage): 2 people, 6.45%
Joint Pain: 2 people, 6.45%
Hypersensitivity: 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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