Janumet and Lenvima drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Janumet (metformin hydrochloride; sitagliptin phosphate) and Lenvima (lenvatinib mesylate). Common drug interactions include vomiting among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Janumet and Lenvima. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Janumet?

Janumet has active ingredients of metformin hydrochloride; sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 25,023 Janumet users. Check the latest studies of Janumet.

What is Lenvima?

Lenvima has active ingredients of lenvatinib mesylate. eHealthMe is studying from 21,113 Lenvima users. Check the latest studies of Lenvima.

On Jul, 10, 2026

17 people who take Janumet and Lenvima together, and have interactions are studied.

What are the common drug interactions of Janumet and Lenvima, by gender? *:

female:

Vomiting
Cystitis (inflammation of the wall of the bladder)
Thyroid disorder (thyroid diseases)
Urinary tract infection
Abdominal pain
Blood pressure decreased
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Cough
Decreased appetite
Fall

male:

Dehydration (dryness resulting from the removal of water)
Blood pressure increased
Vomiting
Asthenia (weakness)
Bedridden
Headache (pain in head)
Pulmonary oedema (fluid accumulation in the lungs)
Stomatitis (inflammation of mucous membrane of mouth)
Ageusia (loss of taste functions of the tongue)
Back pain

What are the common drug interactions of Janumet and Lenvima, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Abdominal discomfort
Blood pressure increased
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Vomiting

60+:

Death
Dehydration (dryness resulting from the removal of water)
Abdominal pain
Blood pressure increased
Dyspnoea (difficult or laboured respiration)
Fall
Haematemesis (vomiting of blood)
Haematochezia (passage of stools containing blood)
Hyperhidrosis (abnormally increased sweating)
Hypertension (high blood pressure)

What are the existing conditions these people have? *

Renal Cell Carcinoma (a kidney cancer): 6 people, 35.29%
Thyroid Cancer: 4 people, 23.53%
Endometrial Cancer: 3 people, 17.65%
Hepatocellular Carcinoma (liver cancer): 1 person, 5.88%
Endometrial Cancer Metastatic: 1 person, 5.88%
Bone Pain: 1 person, 5.88%
Back Pain: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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