Janumet and Loperamide hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Janumet (metformin hydrochloride; sitagliptin phosphate) and Loperamide hydrochloride (loperamide hydrochloride). Common drug interactions include gait disturbance among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Janumet and Loperamide hydrochloride. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Janumet?

Janumet has active ingredients of metformin hydrochloride; sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 25,023 Janumet users. Check the latest studies of Janumet.

What is Loperamide hydrochloride?

Loperamide hydrochloride has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 10,814 Loperamide hydrochloride users. Check the latest studies of Loperamide hydrochloride.

On Aug, 02, 2026

20 people who take Janumet and Loperamide hydrochloride together, and have interactions are studied.

Janumet and Loperamide hydrochloride drug interactions.

What are the common drug interactions of Janumet and Loperamide Hydrochloride, by gender? *:

female:

Gait disturbance
Hypoaesthesia (reduced sense of touch or sensation)
Abdominal pain
Chronic kidney disease
Decreased appetite
Fatigue (feeling of tiredness)
Hyperhidrosis (abnormally increased sweating)
Mucosal inflammation (infection of mucous membrane)
Renal failure (kidney dysfunction)
Blood triglycerides increased

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
General physical health deterioration (weak health status)
Oesophageal varices haemorrhage (bleeding from extremely dilated sub-mucosal veins in the lower third of the oesophagus)
Platelet count decreased
Pneumonia
Weight decreased
Bone density decreased
Bone pain

What are the common drug interactions of Janumet and Loperamide Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blood triglycerides increased
Weight decreased

50-59:

n/a

60+:

Gait disturbance
Hypoaesthesia (reduced sense of touch or sensation)
Fatigue (feeling of tiredness)
Hyperhidrosis (abnormally increased sweating)
Mucosal inflammation (infection of mucous membrane)
Pain
Renal failure (kidney dysfunction)
Aphthous ulcer (mouth ulcer)
Electrolyte imbalance
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)

What are the existing conditions these people have? *

Pain: 9 people, 45.00%
High Blood Pressure: 9 people, 45.00%
Adenocarcinoma Pancreas (cancer of pancreas): 7 people, 35.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 35.00%
Type 2 Diabetes: 3 people, 15.00%
Stress And Anxiety: 2 people, 10.00%
Nasopharyngitis (inflammation of the nasopharynx): 2 people, 10.00%
Affective Disorder (mental disorder): 2 people, 10.00%
Back Pain: 2 people, 10.00%
Bladder Spasm: 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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