Janumet and Nitrostat drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Janumet (metformin hydrochloride; sitagliptin phosphate) and Nitrostat (nitroglycerin). Common drug interactions include hospitalisation among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Janumet and Nitrostat. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Janumet?

Janumet has active ingredients of metformin hydrochloride; sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 25,023 Janumet users. Check the latest studies of Janumet.

What is Nitrostat?

Nitrostat has active ingredients of nitroglycerin. It is often used in chest pain. eHealthMe is studying from 14,082 Nitrostat users. Check the latest studies of Nitrostat.

On Jul, 10, 2026

74 people who take Janumet and Nitrostat together, and have interactions are studied.

Janumet and Nitrostat drug interactions.

What are the common drug interactions of Janumet and Nitrostat, by gender? *:

female:

Hospitalisation
Hypophagia (reduced food intake)
Middle ear effusion (fluid in middle ear)
Nail disorder (disease of nail)
Neuropathy peripheral (surface nerve damage)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Renal injury (kidney injury)
Renal tubular necrosis (death of kidney tubules)
Vision blurred
Visual impairment

male:

Drug ineffective
Chronic kidney disease
Urinary tract infection
Acute myocardial infarction (acute heart attack)
Albumin urine present
Cardiac failure congestive
Cellulitis (infection under the skin)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Creatinine renal clearance decreased
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

What are the common drug interactions of Janumet and Nitrostat, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Arthralgia (joint pain)
Bone pain
Cellulitis (infection under the skin)
Chronic kidney disease
Contusion (a type of hematoma of tissue in which capillaries)
Diarrhoea
Dizziness
Drug hypersensitivity
Dyskinesia (abnormality or impairment of voluntary movement)

50-59:

Anaesthetic complication
Colorectal cancer (colon cancer or bowel cancer)
Haematuria (presence of blood in urine)
Chronic kidney disease
Renal failure (kidney dysfunction)
Albumin urine present
Creatinine renal clearance decreased
Glomerular filtration rate decreased
Haematochezia (passage of stools containing blood)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)

60+:

Chronic kidney disease
Fall
Pneumonia
Renal injury (kidney injury)
Staphylococcal infection (an infection with staphylococcus bacteria)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Urinary tract infection
Cardiac enzymes increased
Cardiac valve disease (heart valve disease)
Drug effect delayed

What are the existing conditions these people have? *

High Blood Pressure: 36 people, 48.65%
High Blood Cholesterol: 30 people, 40.54%
Pain: 25 people, 33.78%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 24 people, 32.43%
Stable Angina (a constant chest pain): 22 people, 29.73%
Cardiac Disorder: 22 people, 29.73%
Depression: 21 people, 28.38%
Nausea (feeling of having an urge to vomit): 20 people, 27.03%
Stress And Anxiety: 18 people, 24.32%
Constipation: 17 people, 22.97%

* Approximation only. Some reports may have incomplete information.

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