Janumet and Premarin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Janumet (metformin hydrochloride; sitagliptin phosphate) and Premarin (estrogens, conjugated). Common drug interactions include anxiety among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Janumet and Premarin. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Janumet?

Janumet has active ingredients of metformin hydrochloride; sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 25,023 Janumet users. Check the latest studies of Janumet.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

On Jul, 26, 2026

81 people who take Janumet and Premarin together, and have interactions are studied.

What are the common drug interactions of Janumet and Premarin, by gender? *:

female:

Anxiety
Asthenia (weakness)
Blindness
Blood pressure increased
Body temperature increased
Chronic kidney disease
Renal failure (kidney dysfunction)
Pancreatitis acute (sudden inflammation of pancreas)
Drug ineffective
Dyspnoea (difficult or laboured respiration)

male:

Chronic kidney disease
Blood glucose increased
Septic shock (shock due to blood infection)
Thrombosis (formation of a blood clot inside a blood vessel)
Visual impairment
Vitreous floaters (spots before the eyes)
Weight decreased
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Memory impairment

What are the common drug interactions of Janumet and Premarin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Ovarian vein thrombosis (clot formation in ovary vein)
Pelvic venous thrombosis (blood clot occurring inside a blood vessel and thromboses (dvts) that form in the deep veins of the legs or in the pelvic veins)

40-49:

Burning sensation
Eye disorder
Thyroid neoplasm (tumour of thyroid)
Visual acuity reduced (reduced clearness of vision)
Chronic kidney disease
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Nephrogenic anaemia (anaemia due to kidney disease)
Papillary thyroid cancer
Renal failure (kidney dysfunction)

50-59:

Renal failure (kidney dysfunction)
Retinal tear
Thrombosis (formation of a blood clot inside a blood vessel)
Visual impairment
Vitreous floaters (spots before the eyes)
Weight decreased
Drug ineffective
Hypertension (high blood pressure)
Memory impairment
Gait disturbance

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Platelet count increased
Pulmonary oedema (fluid accumulation in the lungs)
Renal tubular necrosis (death of kidney tubules)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Systemic inflammatory response syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection)
Vomiting
Adrenal adenoma (benign tumour of the glandular type (adenoma) in the adrenal gland)
Back pain

What are the existing conditions these people have? *

High Blood Pressure: 19 people, 23.46%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 18 people, 22.22%
Depression: 16 people, 19.75%
High Blood Cholesterol: 14 people, 17.28%
Pain: 13 people, 16.05%
Type 2 Diabetes: 12 people, 14.81%
Stress And Anxiety: 12 people, 14.81%
Indigestion: 11 people, 13.58%
Blood Pressure Abnormal: 11 people, 13.58%
Muscle Spasms (muscle contraction): 11 people, 13.58%

* Approximation only. Some reports may have incomplete information.

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