Janumet and Trileptal drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Janumet (metformin hydrochloride; sitagliptin phosphate) and Trileptal (oxcarbazepine). Common drug interactions include neuropathy peripheral among females and balance disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Janumet and Trileptal. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Janumet?

Janumet has active ingredients of metformin hydrochloride; sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 25,023 Janumet users. Check the latest studies of Janumet.

What is Trileptal?

Trileptal has active ingredients of oxcarbazepine. It is often used in bipolar disorder. eHealthMe is studying from 23,558 Trileptal users. Check the latest studies of Trileptal.

On Jul, 11, 2026

20 people who take Janumet and Trileptal together, and have interactions are studied.

Janumet and Trileptal drug interactions.

What are the common drug interactions of Janumet and Trileptal, by gender? *:

female:

Neuropathy peripheral (surface nerve damage)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Flushing (the warm, red condition of human skin)
Herpes zoster oticus (viral infection of the inner, middle, and external ear caused by varicella-zoster virus (vzv))
Limb discomfort (discomfort in leg)
Ludwig angina (a type of cellulitis that involves the floor of the mouth, under the tongue)
Pain
Pruritus (severe itching of the skin)
Blood glucose increased
Cardiac arrest

male:

Balance disorder
Cellulitis (infection under the skin)
Herpes zoster
Lower limb fracture
Memory impairment
Metastases to bone (cancer spreads to bone)
Overdose
Pain
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Sinusitis (inflammation of sinus)

What are the common drug interactions of Janumet and Trileptal, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Lymphoedema (localized fluid retention and tissue swelling)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Pancreatitis (inflammation of pancreas)
Skin discolouration (change of skin colour)
Skin exfoliation (removal of the oldest dead skin cells)
Tardive dyskinesia (a disorder that involves involuntary movements)

50-59:

Pruritus (severe itching of the skin)
Balance disorder
Cardiac arrest
Cellulitis (infection under the skin)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dysarthria (speech disorder)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gait disturbance
Headache (pain in head)

60+:

Hepatocellular injury (liver injury)
Overdose
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 20.00%
High Blood Cholesterol: 4 people, 20.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 15.00%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 3 people, 15.00%
High Blood Pressure: 3 people, 15.00%
Pain: 3 people, 15.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 15.00%
Type 2 Diabetes: 2 people, 10.00%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 2 people, 10.00%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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