Januvia and Cogentin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Januvia (sitagliptin phosphate) and Cogentin (benztropine mesylate). Common drug interactions include diarrhoea among females and back pain among males.

The phase IV clinical study analyzes what interactions people have when they take Januvia and Cogentin. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Januvia?

Januvia has active ingredients of sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 72,818 Januvia users. Check the latest studies of Januvia.

What is Cogentin?

Cogentin has active ingredients of benztropine mesylate. It is often used in tardive dyskinesia. eHealthMe is studying from 7,692 Cogentin users. Check the latest studies of Cogentin.

On Jul, 06, 2026

26 people who take Januvia and Cogentin together, and have interactions are studied.

What are the common drug interactions of Januvia and Cogentin, by gender? *:

female:

Diarrhoea
Dyskinesia (abnormality or impairment of voluntary movement)
Hypersomnia (excessive daytime sleepiness (eds))
Multiple injuries
Nausea (feeling of having an urge to vomit)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Staphylococcus test positive
Aspartate aminotransferase increased
Blood calcium decreased
Blood magnesium decreased

male:

Back pain
Abnormal behaviour
Muscle tightness
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Speech disorder
Anaemia (lack of blood)
Anaemia macrocytic (a macrocytic class of anaemia)
Arthralgia (joint pain)
Benign prostatic hyperplasia (benign enlargement of the prostate)
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)

What are the common drug interactions of Januvia and Cogentin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Anaemia (lack of blood)
Anaemia macrocytic (a macrocytic class of anaemia)
Blood glucose increased
Blood lactate dehydrogenase increased
Chest pain
Chronic myeloid leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood)
Cogwheel rigidity (tension in a muscle which gives way in little jerks when the muscle is stretched)
Dystonia (abnormal muscle tone)
Glycosylated haemoglobin increased
Herpes zoster

20-29:

n/a

30-39:

Ill-defined disorder
Depression
Suicide attempt
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Blood glucose fluctuation
Cardiovascular disorder (heart diseases)
Overdose
Weight increased

40-49:

Drug screen positive
Hypersensitivity

50-59:

Suicidal ideation
Transaminases increased
Blood pressure increased
Chest pain
Feeling of body temperature change
Flushing (the warm, red condition of human skin)
Infusion related reaction
Sinus bradycardia (an unusually slow heartbeat due to heart disease)

60+:

Dyskinesia (abnormality or impairment of voluntary movement)
Arthralgia (joint pain)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pain
Rash
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Abnormal behaviour
Activities of daily living impaired
Aortic arteriosclerosis (hardening of the aortic arteries)
Asthenia (weakness)

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 8 people, 30.77%
Type 2 Diabetes: 3 people, 11.54%
Pain: 3 people, 11.54%
Sleep Disorder: 2 people, 7.69%
Psychotic Disorder: 2 people, 7.69%
Lipidosis (disorder of lipid metabolism involving abnormal accumulation of lipids in the reticuloendothelial cells): 2 people, 7.69%
Insomnia (sleeplessness): 2 people, 7.69%
Indigestion: 2 people, 7.69%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 2 people, 7.69%
Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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