Januvia and Lucentis drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Januvia (sitagliptin phosphate) and Lucentis (ranibizumab). Common drug interactions include dizziness among females and vision blurred among males.

The phase IV clinical study analyzes what interactions people have when they take Januvia and Lucentis. It is created by eHealthMe based on reports of 86 people who take the same drugs from the FDA, and is updated regularly.

What is Januvia?

Januvia has active ingredients of sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 72,818 Januvia users. Check the latest studies of Januvia.

What is Lucentis?

Lucentis has active ingredients of ranibizumab. It is often used in macular degeneration. eHealthMe is studying from 25,647 Lucentis users. Check the latest studies of Lucentis.

On Jul, 09, 2026

86 people who take Januvia and Lucentis together, and have interactions are studied.

What are the common drug interactions of Januvia and Lucentis, by gender? *:

female:

Dizziness
Macular oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken)
Thalamus haemorrhage (bleeding in thalamus)
Vomiting
Blood glucose fluctuation
Eye haemorrhage (bleeding in the eye)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Retinal degeneration (death of the cells of the retina)
Retinal scar (development of scar tissue on retina)
Aneurysm (enlargement of an artery caused by a weakening of the artery wall)

male:

Vision blurred
Cataract (clouding of the lens inside the eye)
Drug intolerance (drug sensitivity)
Gastrointestinal motility disorder (abnormal intestinal contractions)
Renal disorder (kidney disease)
Vitreous floaters (spots before the eyes)
Eye pain
General physical health deterioration (weak health status)
Retinal haemorrhage (bleeding from retina)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

What are the common drug interactions of Januvia and Lucentis, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arteriosclerotic retinopathy (retinal disease caused by arteriosclerosis)
Cataract (clouding of the lens inside the eye)
Halo vision (rainbow vision)
Localised infection (infection at the single location)
Photopsia (presence of perceived flashes of light)
Retinal disorder (disease of retina)
Retinal exudates (discharge from retina)
Retinal haemorrhage (bleeding from retina)
Visual acuity reduced (reduced clearness of vision)
Visual impairment

40-49:

Eye pain
Foreign body sensation in eyes (feeling of something in eye)
Metamorphopsia (a type of distorted vision in which a grid of straight lines appears wavy and parts of the grid may appear blank)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Photopsia (presence of perceived flashes of light)
Vitreous floaters (spots before the eyes)

50-59:

Hyperkeratosis (thickening of the outer layer of the skin)
Lacrimation increased
Macular opacity (opaque macula)
Peripheral swelling
Pupillary reflex impaired
Retinal cyst (cyst on retina)
Retinal scar (development of scar tissue on retina)
Trigeminal neuralgia (a painful condition of the nerve responsible for most facial sensation)
Visual acuity reduced (reduced clearness of vision)
Vitreous floaters (spots before the eyes)

60+:

Vision blurred
Diarrhoea
Drug intolerance (drug sensitivity)
Gastrointestinal motility disorder (abnormal intestinal contractions)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Visual impairment
Anaemia (lack of blood)
Eye pain
Hypotension (abnormally low blood pressure)

What are the existing conditions these people have? *

Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 35 people, 40.70%
Diabetic Retinopathy (damage to the retina caused by complications of diabetes): 20 people, 23.26%
Macular Oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken): 10 people, 11.63%
High Blood Pressure: 9 people, 10.47%
Type 2 Diabetes: 7 people, 8.14%
Retinal Vessel Occlusion (a blockage in one of the small arteries): 6 people, 6.98%
High Blood Cholesterol: 6 people, 6.98%
Age-Related Macular Degeneration: 5 people, 5.81%

* Approximation only. Some reports may have incomplete information.

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