Januvia and Rocephin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Januvia (sitagliptin phosphate) and Rocephin (ceftriaxone sodium). Common drug interactions include oedema peripheral among females and bronchitis among males.

The phase IV clinical study analyzes what interactions people have when they take Januvia and Rocephin. It is created by eHealthMe based on reports of 84 people who take the same drugs from the FDA, and is updated regularly.

What is Januvia?

Januvia has active ingredients of sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 72,818 Januvia users. Check the latest studies of Januvia.

What is Rocephin?

Rocephin has active ingredients of ceftriaxone sodium. It is often used in infection. eHealthMe is studying from 15,665 Rocephin users. Check the latest studies of Rocephin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

84 people who take Januvia and Rocephin together, and have interactions are studied.

What are the common drug interactions of Januvia and Rocephin, by gender? *:

female:

Oedema peripheral (superficial swelling)
Activities of daily living impaired
Arthralgia (joint pain)
Colon cancer metastatic (cancer of colon spreads to other part of body)
Dizziness
Iron deficiency anaemia
Malaise (a feeling of general discomfort or uneasiness)
Asthenia (weakness)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)

male:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest pain
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Abdominal distension
Abdominal pain
Back pain
Cardiomegaly (increased size of heart than normal)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Confusional state
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

What are the common drug interactions of Januvia and Rocephin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pain in extremity
Pulmonary embolism (blockage of the main artery of the lung)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Blood cholesterol increased
Chest pain
Muscle spasms (muscle contraction)
Myalgia (muscle pain)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Activities of daily living impaired

40-49:

Influenza
Myasthenia gravis (a chronic condition that causes muscles to tire and weaken easily)
Nasopharyngitis (inflammation of the nasopharynx)
Anaphylactic reaction (serious allergic reaction)
Cellulitis (infection under the skin)
Chronic kidney disease
Death
Depression
Disturbance in sexual arousal
Nerve injury

50-59:

Abdominal distension
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive
Congestive cardiomyopathy (weakening of heart muscle)
Constipation
Dehydration (dryness resulting from the removal of water)
Fatigue (feeling of tiredness)
Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
Hyperkalaemia (damage to or disease of the kidney)
Intervertebral disc degeneration (spinal disc degeneration)

60+:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Colon cancer metastatic (cancer of colon spreads to other part of body)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac failure
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cardiomegaly (increased size of heart than normal)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Dehydration (dryness resulting from the removal of water)
Diabetes mellitus inadequate control

What are the existing conditions these people have? *

High Blood Pressure: 16 people, 19.05%
Pain: 9 people, 10.71%
Type 2 Diabetes: 8 people, 9.52%
Premenstrual Syndrome: 7 people, 8.33%
Diarrhea: 7 people, 8.33%
High Blood Cholesterol: 6 people, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 7.14%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 6 people, 7.14%
Neuropathy Peripheral (surface nerve damage): 5 people, 5.95%
Cardiac Disorder: 5 people, 5.95%

* Approximation only. Some reports may have incomplete information.

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