Januvia and Sirolimus drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Januvia (sitagliptin phosphate) and Sirolimus (sirolimus). Common drug interactions include melas syndrome among females and interstitial lung disease among males.

The phase IV clinical study analyzes what interactions people have when they take Januvia and Sirolimus. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Januvia?

Januvia has active ingredients of sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 72,818 Januvia users. Check the latest studies of Januvia.

What is Sirolimus?

Sirolimus has active ingredients of sirolimus. eHealthMe is studying from 11,823 Sirolimus users. Check the latest studies of Sirolimus.

On Jul, 19, 2026

24 people who take Januvia and Sirolimus together, and have interactions are studied.

Januvia and Sirolimus drug interactions.

What are the common drug interactions of Januvia and Sirolimus, by gender? *:

female:

Melas syndrome (melas (myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) is a progressive neurodegenerative disorder)
Chest pain
Dyspnoea exertional (breathlessness or shortness of breath)
Erythema (redness of the skin)
Injection site erythema (redness at injection site)
Injection site pain
Injection site pruritus (severe itching at injection site)
Injection site swelling
Rash
Skin lesion

male:

Interstitial lung disease
Decreased appetite
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Fall
Gastritis (inflammation of stomach)
Genital herpes (herpes infection of genital)
Headache (pain in head)
Hyperlipidaemia (presence of excess lipids in the blood)
Infection
Lymphopenia (an abnormally low level of lymphocytes in the blood)

What are the common drug interactions of Januvia and Sirolimus, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Erythema (redness of the skin)
Injection site erythema (redness at injection site)
Injection site pain
Injection site pruritus (severe itching at injection site)
Injection site swelling
Rash
Skin lesion
Somnolence (a state of near-sleep, a strong desire for sleep)
Wound

40-49:

n/a

50-59:

Melas syndrome (melas (myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) is a progressive neurodegenerative disorder)
Blood lactic acid increased
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Confusional state
Diarrhoea
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Stupor (lack of critical cognitive function and level of consciousness)

60+:

Interstitial lung disease
Anaemia macrocytic (a macrocytic class of anaemia)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Fall
Gastritis (inflammation of stomach)
Genital herpes (herpes infection of genital)
Headache (pain in head)
Hyperlipidaemia (presence of excess lipids in the blood)
Infection
Lymphopenia (an abnormally low level of lymphocytes in the blood)

What are the existing conditions these people have? *

Type 2 Diabetes: 6 people, 25.00%
High Blood Pressure: 5 people, 20.83%
Neurodermatitis (a skin disorder characterized by long lasting itching and scratching): 3 people, 12.50%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 3 people, 12.50%
Sinus Congestion (blockage of sinus): 2 people, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 8.33%
Cardiomyopathy (weakening of the heart muscle): 2 people, 8.33%
Constipation: 2 people, 8.33%
Cough: 2 people, 8.33%
Dermatitis Allergic (inflammation of the skin due allergic reaction): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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