Januvia and Zestoretic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Januvia (sitagliptin phosphate) and Zestoretic (hydrochlorothiazide; lisinopril). Common drug interactions include torsade de pointes among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Januvia and Zestoretic. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Januvia?

Januvia has active ingredients of sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 72,818 Januvia users. Check the latest studies of Januvia.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

On Jul, 29, 2026

64 people who take Januvia and Zestoretic together, and have interactions are studied.

Januvia and Zestoretic drug interactions.

What are the common drug interactions of Januvia and Zestoretic, by gender? *:

female:

Torsade de pointes (a abnormal heart rate with abnormal beating pattern)
Abdominal pain
Abdominal pain upper
Alanine aminotransferase increased
Anaemia (lack of blood)
Anaemia vitamin b12 deficiency
Aphagia (inability or refusal to swallow)
Behcet's syndrome (involves inflammation of the blood vessels)
Blood chloride decreased
Blood triglycerides increased

male:

Arthralgia (joint pain)
Pain
Diarrhoea
Emotional distress
Mobility decreased (ability to move is reduced)
Hyperhidrosis (abnormally increased sweating)
Abdominal discomfort
Blood glucose decreased
Chronic kidney disease
Drug ineffective

What are the common drug interactions of Januvia and Zestoretic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Cholecystitis acute (rapid infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diarrhoea
Discomfort
Ear infection
Emotional distress
Haematoma (collection of blood outside the blood vessels)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)

30-39:

n/a

40-49:

Glycosylated haemoglobin decreased
High density lipoprotein decreased
Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate)
Intervertebral disc protrusion (spinal disc protrusion)
Mean platelet volume decreased (less than normal average size of platelet cells in blood)
Red cell distribution width increased
Sleep disorder due to a general medical condition
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Ulcer
Urinary incontinence (inability to control the flow of urine and involuntary urination)

50-59:

Dehydration (dryness resulting from the removal of water)
Peripheral swelling
Asthenia (weakness)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Blood creatinine decreased
Blood glucose increased
Blood parathyroid hormone decreased
Blood sodium decreased
Cytolytic hepatitis (dissolution or destruction of a liver cell)
Dyspepsia (indigestion)

60+:

Chronic kidney disease
Malaise (a feeling of general discomfort or uneasiness)
Asthenia (weakness)
Cardiac arrest
Chest pain
Decreased appetite
Depression
Drug ineffective
Fatigue (feeling of tiredness)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

What are the existing conditions these people have? *

Type 2 Diabetes: 20 people, 31.25%
High Blood Cholesterol: 9 people, 14.06%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 14.06%
Pain: 4 people, 6.25%
Erection Problems: 4 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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