Jentadueto and Digoxin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Jentadueto (linagliptin; metformin hydrochloride) and Digoxin (digoxin). Common drug interactions include abdominal pain among females and basal ganglia haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Jentadueto and Digoxin. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Jentadueto?

Jentadueto has active ingredients of linagliptin; metformin hydrochloride. eHealthMe is studying from 1,319 Jentadueto users. Check the latest studies of Jentadueto.

What is Digoxin?

Digoxin has active ingredients of digoxin. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 93,740 Digoxin users. Check the latest studies of Digoxin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

12 people who take Jentadueto and Digoxin together, and have interactions are studied.

Jentadueto and Digoxin drug interactions.

What are the common drug interactions of Jentadueto and Digoxin, by gender? *:

female:

Abdominal pain
Abdominal wall haematoma (abdominal wall blood clotting)
Blood glucose increased
Cardioactive drug level increased
Cough
Dysphagia (a condition in which swallowing is difficult or painful)
Gastritis (inflammation of stomach)
Haemorrhage (bleeding)
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
International normalised ratio increased

male:

Basal ganglia haemorrhage (bleeding from blood vessels in an area of the brain responsible for body movements)
Cardiac failure
Cataract (clouding of the lens inside the eye)
Vomiting
Anxiety
Blood glucose increased
Pneumonia

What are the common drug interactions of Jentadueto and Digoxin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Diarrhoea
Gastroenteritis (inflammation of stomach and intestine)
Vomiting
Migraine (headache)
Nausea (feeling of having an urge to vomit)

50-59:

n/a

60+:

Basal ganglia haemorrhage (bleeding from blood vessels in an area of the brain responsible for body movements)
Vomiting
Gastritis (inflammation of stomach)
Haemorrhage (bleeding)
International normalised ratio increased
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pneumonia
Retching (strong involuntary effort to vomit)
Blood glucose increased
Cardiac failure

What are the existing conditions these people have? *

Type 2 Diabetes: 5 people, 41.67%
High Blood Pressure: 4 people, 33.33%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 4 people, 33.33%
High Blood Cholesterol: 3 people, 25.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 16.67%
Heart Rate Irregular: 1 person, 8.33%
Blood Pressure Abnormal: 1 person, 8.33%
Cardiac Disorder: 1 person, 8.33%
Cardiac Failure Congestive: 1 person, 8.33%
Depression: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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