Kadian and Naprosyn drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Kadian (morphine sulfate) and Naprosyn (naproxen). Common drug interactions include arteriosclerosis among females and dyspnoea among males.
The phase IV clinical study analyzes what interactions people have when they take Kadian and Naprosyn. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.
What is Kadian?
Kadian has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 23,045 Kadian users. Check the latest studies of Kadian.
What is Naprosyn?
Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.
62 people who take Kadian and Naprosyn together, and have interactions are studied.

What are the common drug interactions of Kadian and Naprosyn, by gender? *:
female:
- Arteriosclerosis (thickening and hardening of arteries)
- Pulmonary congestion (congestion in the lungs)
- Anaemia (lack of blood)
- Angina pectoris (chest pain due to ischemia of the heart muscle)
- Ataxia (loss of full control of bodily movements)
- Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
- Bone disorder
- Cataract (clouding of the lens inside the eye)
- Cerebral artery stenosis (hardening of brain blood vessels)
- Cerebrosclerosis (hardening of the substance of the cerebrum)
male:
- Dyspnoea (difficult or laboured respiration)
- Anxiety
- Haematuria (presence of blood in urine)
- Hallucination (an experience involving the perception of something not present)
- Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
- Osteomyelitis (infection of bone)
- Paraplegia (paralysis of the legs and lower body)
- Sleep disorder due to a general medical condition
- Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
- Blood calcium decreased
What are the common drug interactions of Kadian and Naprosyn, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
- Contusion (a type of hematoma of tissue in which capillaries)
- Hepatic steatosis (fatty liver disease)
- Varicose vein (veins that have become enlarged and tortuous)
- Aortic valve stenosis (narrowing of the aortic valve)
- Drug screen positive
- Hepatomegaly (abnormal enlargement of the liver)
- Skin striae (irregular areas of skin that look like bands, stripes, or lines)
- Cough
- Death
- Hepatitis (inflammation of the liver)
50-59:
n/a
60+:
- Osteomyelitis (infection of bone)
- Bone disorder
- Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
- Confusional state
- Decreased interest
- Dysphagia (a condition in which swallowing is difficult or painful)
- Dyspnoea (difficult or laboured respiration)
- General physical health deterioration (weak health status)
- Haematuria (presence of blood in urine)
- Hallucination (an experience involving the perception of something not present)
What are the existing conditions these people have? *
- Multiple Myeloma (cancer of the plasma cells): 30 people, 48.39%
- Back Pain: 12 people, 19.35%
- Stress And Anxiety: 11 people, 17.74%
- Metastases To Bone (cancer spreads to bone): 10 people, 16.13%
- Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 10 people, 16.13%
- Gout (uric acid crystals building up in the body): 10 people, 16.13%
- Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 10 people, 16.13%
- Dizziness: 10 people, 16.13%
- Breast Cancer: 10 people, 16.13%
- Bone Pain: 10 people, 16.13%
* Approximation only. Some reports may have incomplete information.
Do you take Kadian and Naprosyn?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Kadian and Naprosyn:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Kadian:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Naprosyn:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Kadian and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Naprosyn and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Rasmy A, Rahal M, Kisana M, Ahmad S, Salah A, "Morphine induced thrombocytopenia: A case report", Journal of Case Reports and Images in Oncology, 2015 Dec .
- Rasmy A, Rahal M, Kisana M, Ahmad S, Salah A, "Morphine induced thrombocytopenia: A case report", Journal of Case Reports and Images in Oncology, 2015 Dec .
How the study uses the data?
The study uses data from the FDA. It is based on morphine sulfate and naproxen (the active ingredients of Kadian and Naprosyn, respectively), and Kadian and Naprosyn (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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