Keppra and Amoxil drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Keppra (levetiracetam) and Amoxil (amoxicillin). Common drug interactions include temporomandibular joint syndrome among females and headache among males.
The phase IV clinical study analyzes what interactions people have when they take Keppra and Amoxil. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.
What is Keppra?
Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.
What is Amoxil?
Amoxil has active ingredients of amoxicillin. It is often used in infection. eHealthMe is studying from 3,641 Amoxil users. Check the latest studies of Amoxil.
44 people who take Keppra and Amoxil together, and have interactions are studied.

What are the common drug interactions of Keppra and Amoxil, by gender? *:
female:
- Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)
- Pyrexia (fever)
- Anaemia (lack of blood)
- Burning sensation
- Influenza
- Retching (strong involuntary effort to vomit)
- Viral infection
- Carotid artery occlusion (artery blockage)
- Carotid artery stenosis (narrowing of carotid artery)
- Deformity (disfigurement)
male:
- Headache (pain in head)
- Hypoaesthesia (reduced sense of touch or sensation)
- Neuropathy peripheral (surface nerve damage)
- Tremor (trembling or shaking movements in one or more parts of your body)
- Abdominal pain
- Adverse event
- Anxiety disorder
- Aphasia (damage to the parts of the brain that control language)
- Asthenia (weakness)
- Ataxia (loss of full control of bodily movements)
What are the common drug interactions of Keppra and Amoxil, by age (0-1 to 60+)? *:
0-1:
- Constipation
- Cough
- Diarrhoea
- Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
- Otitis media (inflammation of the middle ear)
- Pyrexia (fever)
- Rhinorrhoea (watery mucus discharge from the nose)
- Tachycardia (a heart rate that exceeds the range of 100 beats/min)
- Upper respiratory tract infection
- Anaemia (lack of blood)
2-9:
n/a
10-19:
- Malaise (a feeling of general discomfort or uneasiness)
- Pain
- Vomiting
- Abdominal pain
- Decreased appetite
- Dehydration (dryness resulting from the removal of water)
- Dizziness
- Nausea (feeling of having an urge to vomit)
- Blood bilirubin increased
- Hyperglycaemia (high blood sugar)
20-29:
n/a
30-39:
- Dyspepsia (indigestion)
- Febrile neutropenia (fever with reduced white blood cells)
- Hypotension (abnormally low blood pressure)
- Abdominal pain upper
- Dizziness
- Epigastric discomfort
- Nausea (feeling of having an urge to vomit)
- Pyrexia (fever)
- Vomiting
40-49:
- Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
- Ataxia (loss of full control of bodily movements)
- Balance disorder
- Blood pressure decreased
- Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
- Cerebral atrophy (decrement in size of brain)
- Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
- Communication disorder (speech and language disorder)
- Confusional state
- Contusion (a type of hematoma of tissue in which capillaries)
50-59:
- Chest injury
- Cough
- Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
- Drug hypersensitivity
- Fall
- Head injury
- Headache (pain in head)
- Hilar lymphadenopathy (disease of the lymph nodes due to infection)
- Hypoaesthesia (reduced sense of touch or sensation)
- Injury
60+:
- Dysphagia (a condition in which swallowing is difficult or painful)
- Gait disturbance
- Sensation of foreign body
- Tinnitus (a ringing in the ears)
- Blindness
- Dizziness
- Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
- Neck pain
- Nervous system disorder (a general class of medical conditions affecting the nervous system)
- Postnasal drip
What are the existing conditions these people have? *
- Pain: 14 people, 31.82%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 31.82%
- Seizures (abnormal excessive or synchronous neuronal activity in the brain): 7 people, 15.91%
- Nausea (feeling of having an urge to vomit): 6 people, 13.64%
- Cough: 6 people, 13.64%
- Wheezing (a high-pitched whistling sound made while you breath): 5 people, 11.36%
- Fever: 5 people, 11.36%
- Nausea And Vomiting: 4 people, 9.09%
- Dyspnea (difficult or laboured breathing): 4 people, 9.09%
- Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 4 people, 9.09%
* Approximation only. Some reports may have incomplete information.
Do you take Keppra and Amoxil?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Keppra and Amoxil:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Keppra:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Amoxil:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Keppra and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Amoxil and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Schattner A, Al-Bewerat A, "Levetiracetam (Keppra), urinary retention and literature search", A fatty cause of renal failure; what is your diagnosis?, 2016 Oct .
- Spengler DC, Montouris GD, Hohler AD, "Levetiracetam as a possible contributor to acute kidney injury", Clinical therapeutics, 2014 Aug .
- Almeida DM, Jean MR, Chystsiakova A, Monahan E, Oliveira SB, Monteiro IM, "Levetiracetam-associated acute pancreatitis in an adolescent with autism: a case report", Pancreas, 2013 Jan .
- Schattner A, Al-Bewerat A, "Levetiracetam (Keppra), urinary retention and literature search", A fatty cause of renal failure; what is your diagnosis?, 2016 Oct .
- Spengler DC, Montouris GD, Hohler AD, "Levetiracetam as a possible contributor to acute kidney injury", Clinical therapeutics, 2014 Aug .
- Almeida DM, Jean MR, Chystsiakova A, Monahan E, Oliveira SB, Monteiro IM, "Levetiracetam-associated acute pancreatitis in an adolescent with autism: a case report", Pancreas, 2013 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on levetiracetam and amoxicillin (the active ingredients of Keppra and Amoxil, respectively), and Keppra and Amoxil (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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