Keppra and Cholbam drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Keppra (levetiracetam) and Cholbam (cholic acid). Common drug interactions include death among females and death among males.
The phase IV clinical study analyzes what interactions people have when they take Keppra and Cholbam. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.
What is Keppra?
Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.
What is Cholbam?
Cholbam has active ingredients of cholic acid. eHealthMe is studying from 264 Cholbam users. Check the latest studies of Cholbam.
11 people who take Keppra and Cholbam together, and have interactions are studied.

What are the common drug interactions of Keppra and Cholbam, by gender? *:
female:
- Death
- Diarrhoea
- Infection
- Dyspnoea (difficult or laboured respiration)
- Epistaxis (bleed from the nose)
- Hepatomegaly (abnormal enlargement of the liver)
- Hospitalisation
- Interstitial lung disease
- Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
- Tonsillar hypertrophy (enlargement of the tonsils)
male:
- Death
- Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
- Productive cough
- Pyrexia (fever)
- Rhinorrhoea (watery mucus discharge from the nose)
- Vomiting
- Hospitalisation
- Renal failure (kidney dysfunction)
- Venoocclusive liver disease (small veins in the liver are obstructed)
- Diarrhoea
What are the common drug interactions of Keppra and Cholbam, by age (0-1 to 60+)? *:
0-1:
- Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
- Hospitalisation
- Infection
- Renal failure (kidney dysfunction)
- Venoocclusive liver disease (small veins in the liver are obstructed)
- Hepatomegaly (abnormal enlargement of the liver)
- Productive cough
- Pyrexia (fever)
- Rhinorrhoea (watery mucus discharge from the nose)
- Urinary tract infection
2-9:
- Interstitial lung disease
- Viral infection
10-19:
- Diarrhoea
- Gastric infection (infection of stomach)
- Irritability
- Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
- Pain
- Vomiting
20-29:
n/a
30-39:
n/a
40-49:
n/a
50-59:
n/a
60+:
n/a
What are the existing conditions these people have? *
- Cerebrohepatorenal Syndrome (absence of functional organelles in brain cells (by birth disorder )): 7 people, 63.64%
- Metabolic Disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues): 2 people, 18.18%
* Approximation only. Some reports may have incomplete information.
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Keppra and Cholbam:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Keppra:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Cholbam:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Keppra and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Cholbam and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Schattner A, Al-Bewerat A, "Levetiracetam (Keppra), urinary retention and literature search", A fatty cause of renal failure; what is your diagnosis?, 2016 Oct .
- Spengler DC, Montouris GD, Hohler AD, "Levetiracetam as a possible contributor to acute kidney injury", Clinical therapeutics, 2014 Aug .
- Almeida DM, Jean MR, Chystsiakova A, Monahan E, Oliveira SB, Monteiro IM, "Levetiracetam-associated acute pancreatitis in an adolescent with autism: a case report", Pancreas, 2013 Jan .
- Schattner A, Al-Bewerat A, "Levetiracetam (Keppra), urinary retention and literature search", A fatty cause of renal failure; what is your diagnosis?, 2016 Oct .
- Spengler DC, Montouris GD, Hohler AD, "Levetiracetam as a possible contributor to acute kidney injury", Clinical therapeutics, 2014 Aug .
- Almeida DM, Jean MR, Chystsiakova A, Monahan E, Oliveira SB, Monteiro IM, "Levetiracetam-associated acute pancreatitis in an adolescent with autism: a case report", Pancreas, 2013 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on levetiracetam and cholic acid (the active ingredients of Keppra and Cholbam, respectively), and Keppra and Cholbam (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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