Keppra and Tadalafil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Keppra (levetiracetam) and Tadalafil (tadalafil). Common drug interactions include ascites among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Keppra and Tadalafil. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Keppra?

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.

What is Tadalafil?

Tadalafil has active ingredients of tadalafil. It is often used in erection problems. eHealthMe is studying from 25,548 Tadalafil users. Check the latest studies of Tadalafil.

On Jul, 21, 2026

36 people who take Keppra and Tadalafil together, and have interactions are studied.

What are the common drug interactions of Keppra and Tadalafil, by gender? *:

female:

Ascites (accumulation of fluid in the abdominal cavity)
Bacterial sepsis
Cerebral thrombosis (blood clot in brain)
Chest pain
Cough
Dizziness postural
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Exercise tolerance decreased
Fluid overload (too much fluid in the blood)

male:

Pain
Alanine aminotransferase increased
Nausea (feeling of having an urge to vomit)
Patient-device incompatibility
Abdominal pain
Blood bilirubin increased
Bowel movement irregularity
Facial bones fracture (bone fracture of face)
Fall
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

What are the common drug interactions of Keppra and Tadalafil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Infusion site pain
Infusion site reaction
Pain
Patient-device incompatibility
Asthenia (weakness)
Nausea (feeling of having an urge to vomit)
Upper respiratory tract infection
Respiratory failure (inadequate gas exchange by the respiratory system)
Tracheostomy infection (infection of trachea surgical opening)
Infusion site inflammation

10-19:

Food intolerance (inability to have food)
Retching (strong involuntary effort to vomit)
Sinusitis (inflammation of sinus)

20-29:

n/a

30-39:

Pain
Abdominal distension
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthralgia (joint pain)
Back pain
Blood glucose increased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Chest discomfort
Depression
Disability

40-49:

Alanine aminotransferase increased
Altered state of consciousness (altered state of mind)
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Hepatic congestion (liver congestion)
Hypoxia (low oxygen in tissues)
Malaise (a feeling of general discomfort or uneasiness)
Oxygen saturation decreased
Right ventricular failure (right half of the heart fails to work)
Seizure anoxic (a reflex anoxic seizure is a type of fit triggered by a temporary cutting off of the supply of blood to the brain)

50-59:

Abdominal pain
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Blood bilirubin increased
Bowel movement irregularity
Facial bones fracture (bone fracture of face)
Fatigue (feeling of tiredness)
Headache (pain in head)
Hospitalisation

60+:

Fall
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Eye pain
Flatulence (flatus expelled through the anus)
Groin pain
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Hypotension (abnormally low blood pressure)
Malignant palate neoplasm (cancer tumour of roof of mouth)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 19 people, 52.78%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 5 people, 13.89%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 5 people, 13.89%
Hypersensitivity: 3 people, 8.33%
Nausea And Vomiting: 2 people, 5.56%
Nausea (feeling of having an urge to vomit): 2 people, 5.56%
Multiple Myeloma (cancer of the plasma cells): 2 people, 5.56%
Intracardiac Thrombus (presence of a circumscribed mass with heart wall): 2 people, 5.56%
Glioblastoma Multiforme (most common and deadliest of malignant primary brain tumours in adults): 2 people, 5.56%
Fainting (loss of consciousness and postural tone): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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