Keppra and Tradjenta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Keppra (levetiracetam) and Tradjenta (linagliptin). Common drug interactions include erythema among females and cerebrovascular accident among males.

The phase IV clinical study analyzes what interactions people have when they take Keppra and Tradjenta. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Keppra?

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.

What is Tradjenta?

Tradjenta has active ingredients of linagliptin. It is often used in diabetes. eHealthMe is studying from 9,987 Tradjenta users. Check the latest studies of Tradjenta.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

50 people who take Keppra and Tradjenta together, and have interactions are studied.

What are the common drug interactions of Keppra and Tradjenta, by gender? *:

female:

Erythema (redness of the skin)
Fall
Feeling hot
Fungal infection
Gait disturbance
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Headache (pain in head)
Hot flush (sudden feelings of heat)
Hyperhidrosis (abnormally increased sweating)
Hypophagia (reduced food intake)

male:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Aortic valve replacement
Tooth infection
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Abdominal pain
Acute respiratory failure
Anaemia (lack of blood)
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Blood glucose decreased
Blood glucose increased

What are the common drug interactions of Keppra and Tradjenta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Hyperlipidaemia (presence of excess lipids in the blood)
Hypertension (high blood pressure)
Inflammation
Migraine (headache)
Pneumonia
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Emotional distress
Epistaxis (bleed from the nose)

50-59:

Anaemia (lack of blood)
Hypotension (abnormally low blood pressure)
Neuropathy peripheral (surface nerve damage)
Restless legs syndrome (a powerful urge to move your legs)
Weight decreased
Knee arthroplasty
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pneumonia
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Death

60+:

Asthenia (weakness)
Dizziness
Death
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Fatigue (feeling of tiredness)
Nephrolithiasis (calculi in the kidneys)
Tooth infection
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Syncope (loss of consciousness with an inability to maintain postural tone)
Abdominal pain upper

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 18.00%
Hyperkalemia (damage to or disease of the kidney): 6 people, 12.00%
Type 2 Diabetes: 5 people, 10.00%
Thyroid Diseases: 5 people, 10.00%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 5 people, 10.00%
High Blood Cholesterol: 5 people, 10.00%
Stress And Anxiety: 4 people, 8.00%
High Blood Pressure: 4 people, 8.00%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 3 people, 6.00%
Renal Cell Carcinoma (a kidney cancer): 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

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