Ketoconazole and Adempas drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ketoconazole (ketoconazole) and Adempas (riociguat). Common drug interactions include somnolence among females and syncope among males.

The phase IV clinical study analyzes what interactions people have when they take Ketoconazole and Adempas. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Ketoconazole?

Ketoconazole has active ingredients of ketoconazole. It is often used in fungal infection. eHealthMe is studying from 16,014 Ketoconazole users. Check the latest studies of Ketoconazole.

What is Adempas?

Adempas has active ingredients of riociguat. eHealthMe is studying from 29,741 Adempas users. Check the latest studies of Adempas.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

23 people who take Ketoconazole and Adempas together, and have interactions are studied.

Ketoconazole and Adempas drug interactions.

What are the common drug interactions of Ketoconazole and Adempas, by gender? *:

female:

Somnolence (a state of near-sleep, a strong desire for sleep)
Throat irritation
Headache (pain in head)
Arthralgia (joint pain)
Constipation
Hospitalisation
Hypersensitivity
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Nerve injury

male:

Syncope (loss of consciousness with an inability to maintain postural tone)
Anxiety
Alanine aminotransferase decreased
Blood creatinine increased
Blood glucose increased
Carbon dioxide decreased
Chest pain
Chills (felling of cold)
Constipation
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)

What are the common drug interactions of Ketoconazole and Adempas, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Arthralgia (joint pain)
Constipation
Headache (pain in head)
Hospitalisation
Hypersensitivity
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Nerve injury
Pain in extremity
Pain in jaw

50-59:

Anxiety
Productive cough
Weight decreased
Fatigue (feeling of tiredness)
Syncope (loss of consciousness with an inability to maintain postural tone)
Alanine aminotransferase decreased
Blood creatinine increased
Blood glucose increased
Carbon dioxide decreased
Chest pain

60+:

Dyspnoea (difficult or laboured respiration)
Syncope (loss of consciousness with an inability to maintain postural tone)
Rib fracture
Anaemia (lack of blood)
Arthralgia (joint pain)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Bradycardia (abnormally slow heart action)
Cellulitis (infection under the skin)
Death

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 15 people, 65.22%
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 4 people, 17.39%

* Approximation only. Some reports may have incomplete information.

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