Ketoconazole and Apriso drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ketoconazole (ketoconazole) and Apriso (mesalamine). Common drug interactions include cough among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Ketoconazole and Apriso. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Ketoconazole?

Ketoconazole has active ingredients of ketoconazole. It is often used in fungal infection. eHealthMe is studying from 16,014 Ketoconazole users. Check the latest studies of Ketoconazole.

What is Apriso?

Apriso has active ingredients of mesalamine. It is often used in ulcerative colitis. eHealthMe is studying from 3,439 Apriso users. Check the latest studies of Apriso.



On Jul, 09, 2026

13 people who take Ketoconazole and Apriso together, and have interactions are studied.

Ketoconazole and Apriso drug interactions.

What are the common drug interactions of Ketoconazole and Apriso, by gender? *:

female:

  1. Cough
  2. Fatigue (feeling of tiredness)
  3. Chronic kidney disease
  4. Drug ineffective
  5. Dyspnoea (difficult or laboured respiration)
  6. Rash
  7. Anxiety
  8. Arteriosclerosis (thickening and hardening of arteries)
  9. Back pain
  10. Blood glucose increased

male:

  1. Fatigue (feeling of tiredness)
  2. Diarrhoea
  3. Fracture
  4. Hypoaesthesia (reduced sense of touch or sensation)
  5. Osteonecrosis (death of bone)
  6. Pain
  7. Tooth loss
  8. Tremor (trembling or shaking movements in one or more parts of your body)
  9. Frequent bowel movements
  10. Anhedonia (inability to experience pleasure from activities usually found enjoyable)

What are the common drug interactions of Ketoconazole and Apriso, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Bone density decreased
  4. Bone loss
  5. Chronic kidney disease
  6. Emotional distress
  7. Fracture
  8. Osteonecrosis (death of bone)
  9. Pain
  10. Tooth loss

40-49:

n/a

50-59:

  1. Chronic kidney disease

60+:

  1. Fatigue (feeling of tiredness)
  2. Anxiety
  3. Fluid retention (an abnormal accumulation of fluid in the blood)
  4. Frequent bowel movements
  5. Glycosylated haemoglobin increased
  6. Hypoaesthesia (reduced sense of touch or sensation)
  7. Insomnia (sleeplessness)
  8. Mobility decreased (ability to move is reduced)
  9. Muscle tightness
  10. Peripheral swelling

What are the existing conditions these people have? *

  1. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 30.77%
  2. Immunodeficiency Common Variable: 3 people, 23.08%
  3. Cardiac Disorder: 3 people, 23.08%
  4. Wheezing (a high-pitched whistling sound made while you breath): 2 people, 15.38%
  5. Gout (uric acid crystals building up in the body): 2 people, 15.38%
  6. Rashes (redness): 2 people, 15.38%
  7. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 15.38%
  8. Rosacea (a skin condition that causes facial redness): 2 people, 15.38%
  9. Pain: 2 people, 15.38%
  10. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

Do you take Ketoconazole and Apriso?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Ketoconazole and Apriso:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ketoconazole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Apriso:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ketoconazole and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Apriso and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on ketoconazole and mesalamine (the active ingredients of Ketoconazole and Apriso, respectively), and Ketoconazole and Apriso (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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