Ketoconazole and Invokana drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ketoconazole (ketoconazole) and Invokana (canagliflozin). Common drug interactions include chest pain among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Ketoconazole and Invokana. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Ketoconazole?

Ketoconazole has active ingredients of ketoconazole. It is often used in fungal infection. eHealthMe is studying from 16,014 Ketoconazole users. Check the latest studies of Ketoconazole.

What is Invokana?

Invokana has active ingredients of canagliflozin. It is often used in diabetes. eHealthMe is studying from 29,937 Invokana users. Check the latest studies of Invokana.

On Aug, 06, 2026

37 people who take Ketoconazole and Invokana together, and have interactions are studied.

Ketoconazole and Invokana drug interactions.

What are the common drug interactions of Ketoconazole and Invokana, by gender? *:

female:

Chest pain
Headache (pain in head)
Anxiety
Arthralgia (joint pain)
Asthenia (weakness)
Chronic kidney disease
Diarrhoea
Eye disorder
Injection site pain
Rash

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Groin abscess (pus in groin)
Leukocytosis (increased white blood cells)
Scrotal abscess (pus in scrotum)
Testicular abscess (pus in testes)
Tooth abscess (pus formation in tooth)
Sepsis (a severe blood infection that can lead to organ failure and death)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone density decreased

What are the common drug interactions of Ketoconazole and Invokana, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)

30-39:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)

40-49:

Abscess limb (limb infection)
Cellulitis (infection under the skin)
Cellulitis of male external genital organ (infection of male genitals soft tissue)
Cellulitis staphylococcal (a type of bacteria originated skin soft tissue infection)
Gangrene (body tissue dies)
Groin abscess (pus in groin)
Leukocytosis (increased white blood cells)
Scrotal abscess (pus in scrotum)
Testicular abscess (pus in testes)
Tooth abscess (pus formation in tooth)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Jaundice cholestatic
Pancreatitis acute (sudden inflammation of pancreas)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Adenocarcinoma pancreas (cancer of pancreas)
Anxiety
Death
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Dyspepsia (indigestion)

60+:

Anxiety
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Death
Drug hypersensitivity
Insomnia (sleeplessness)
Tardive dyskinesia (a disorder that involves involuntary movements)
Agitation (state of anxiety or nervous excitement)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Dizziness
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Pain: 16 people, 43.24%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 15 people, 40.54%
High Blood Pressure: 13 people, 35.14%
Hypersensitivity: 12 people, 32.43%
High Blood Cholesterol: 12 people, 32.43%
Infection: 9 people, 24.32%
Type 2 Diabetes: 8 people, 21.62%
Cough: 7 people, 18.92%
Gout (uric acid crystals building up in the body): 6 people, 16.22%
Headache (pain in head): 6 people, 16.22%

* Approximation only. Some reports may have incomplete information.

Do you take Ketoconazole and Invokana?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously