Ketoprofen and Norco drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ketoprofen (ketoprofen) and Norco (acetaminophen; hydrocodone bitartrate). Common drug interactions include delirium among females and drug hypersensitivity among males.

The phase IV clinical study analyzes what interactions people have when they take Ketoprofen and Norco. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Ketoprofen?

Ketoprofen has active ingredients of ketoprofen. It is often used in pain. eHealthMe is studying from 15,048 Ketoprofen users. Check the latest studies of Ketoprofen.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,063 Norco users. Check the latest studies of Norco.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

37 people who take Ketoprofen and Norco together, and have interactions are studied.

What are the common drug interactions of Ketoprofen and Norco, by gender? *:

female:

Delirium (wild excitement)
Dyspnoea (difficult or laboured respiration)
Postoperative wound infection
Rash
Renal failure acute (rapid kidney dysfunction)
Staphylococcal infection (an infection with staphylococcus bacteria)
Abdominal distension
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Anxiety

male:

Drug hypersensitivity
Drug ineffective
Abdominal pain
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Chest pain
Chills (felling of cold)
Cough
Eructation (release of gas from the digestive tract)
Infection
Influenza

What are the common drug interactions of Ketoprofen and Norco, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal distension
Abdominal pain
Abdominal pain upper
Gastric haemorrhage (bleeding stomach)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Liver disorder (liver diseases)
Nausea (feeling of having an urge to vomit)
Overdose
Renal disorder (kidney disease)

40-49:

Delirium (wild excitement)
Postoperative wound infection
Rash
Renal failure acute (rapid kidney dysfunction)
Staphylococcal infection (an infection with staphylococcus bacteria)

50-59:

Hypotension (abnormally low blood pressure)
Anxiety
Asthenia (weakness)
Cardiac disorder
Chest pain
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Renal failure (kidney dysfunction)
Chronic kidney disease
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)

60+:

Drug ineffective
Intervertebral disc degeneration (spinal disc degeneration)
Chills (felling of cold)
Chronic kidney disease
Cough
Eructation (release of gas from the digestive tract)
Hand deformity
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Infection
Influenza

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 8 people, 21.62%
Sleep Disorder: 4 people, 10.81%
Haemostasis (stopping of bleeding): 4 people, 10.81%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 10.81%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 8.11%
High Blood Pressure: 3 people, 8.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 8.11%
Drowsiness: 3 people, 8.11%
Rickets (softening of bones): 2 people, 5.41%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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