Keytruda and Atarax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Keytruda (pembrolizumab) and Atarax (hydroxyzine hydrochloride). Common drug interactions include pleural effusion among females and interstitial lung disease among males.

The phase IV clinical study analyzes what interactions people have when they take Keytruda and Atarax. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Keytruda?

Keytruda has active ingredients of pembrolizumab. It is often used in renal cell carcinoma. eHealthMe is studying from 57,404 Keytruda users. Check the latest studies of Keytruda.

What is Atarax?

Atarax has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 23,553 Atarax users. Check the latest studies of Atarax.

On Aug, 07, 2026

46 people who take Keytruda and Atarax together, and have interactions are studied.

What are the common drug interactions of Keytruda and Atarax, by gender? *:

female:

Pleural effusion (water on the lungs)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Lichenoid keratosis (a skin disorder described by rapid growing, reddish to brown, benign (noncancerous) lesion on the skin)
Mucosal inflammation (infection of mucous membrane)
Muscle injury
Pulmonary sarcoidosis (growth of tiny collections of inflammatory cells in lungs)
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Death

male:

Interstitial lung disease
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Fatigue (feeling of tiredness)
Gait disturbance
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Oedema (fluid collection in tissue)
Pemphigoid (tense blisters on the skin)
Rash

What are the common drug interactions of Keytruda and Atarax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)

40-49:

Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Scleroderma (hard skin)

50-59:

Pleural effusion (water on the lungs)
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Death
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Herpes zoster
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Pneumonia
Pyrexia (fever)
Rash

60+:

Interstitial lung disease
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Proteinuria (presence of protein in the urine)
Anaemia (lack of blood)
Bone pain
Cellulitis (infection under the skin)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Fatigue (feeling of tiredness)
Gait disturbance
Hypercalcaemia (elevated calcium (ca+) level in the blood)

What are the existing conditions these people have? *

Depression: 19 people, 41.30%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 14 people, 30.43%
Bronchial Carcinoma (lung cancer): 14 people, 30.43%
Vitamin B12 Deficiency: 13 people, 28.26%
Non-Small Cell Lung Cancer Stage Iv: 13 people, 28.26%
High Blood Cholesterol: 13 people, 28.26%
Diabetes: 13 people, 28.26%
Lung Neoplasm Malignant (cancer tumour of lung): 11 people, 23.91%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 6 people, 13.04%
Gait Disturbance: 6 people, 13.04%

* Approximation only. Some reports may have incomplete information.

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