Keytruda and Breo ellipta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Keytruda (pembrolizumab) and Breo ellipta (fluticasone furoate; vilanterol trifenatate). Common drug interactions include atrial fibrillation among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Keytruda and Breo ellipta. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Keytruda?

Keytruda has active ingredients of pembrolizumab. It is often used in renal cell carcinoma. eHealthMe is studying from 57,404 Keytruda users. Check the latest studies of Keytruda.

What is Breo ellipta?

Breo ellipta has active ingredients of fluticasone furoate; vilanterol trifenatate. It is often used in asthma. eHealthMe is studying from 37,362 Breo ellipta users. Check the latest studies of Breo ellipta.

On Aug, 08, 2026

37 people who take Keytruda and Breo ellipta together, and have interactions are studied.

Keytruda and Breo ellipta drug interactions.

What are the common drug interactions of Keytruda and Breo Ellipta, by gender? *:

female:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Pulmonary embolism (blockage of the main artery of the lung)
Skin toxicity (skin damage due to toxin/poison)
Adverse event
Blood thyroid stimulating hormone increased

male:

Death
Dyspnoea (difficult or laboured respiration)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Abdominal pain
Abdominal pain upper
Acute respiratory failure
Appetite disorder (abnormal eating habits)
Back pain
Blood pressure increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

What are the common drug interactions of Keytruda and Breo Ellipta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)
Bone pain
Death
Fatigue (feeling of tiredness)
Sleep disorder

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Hypokalaemia (low potassium)
Pneumonia
Abdominal pain upper
Deafness
Decreased appetite
Dyspepsia (indigestion)
Fatigue (feeling of tiredness)
Feeding disorder (when children refuse to eat certain food groups)
Gait disturbance

What are the existing conditions these people have? *

Lung Neoplasm Malignant (cancer tumour of lung): 9 people, 24.32%
Lung Adenocarcinoma Stage Iv (the cancer has spread to other organs of the body, such as the other lung, brain, or liver): 9 people, 24.32%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 2 people, 5.41%
Malignant Neoplasm Progression (cancer tumour came back): 2 people, 5.41%
Lung Carcinoma Cell Type Unspecified Stage 0 (the lung cancer has not spread beyond the inner lining of the lung): 2 people, 5.41%
Lung Cancer - Non-Small Cell (lung cancer): 2 people, 5.41%
Endometrial Cancer: 2 people, 5.41%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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