Keytruda and Vancomycin hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Keytruda (pembrolizumab) and Vancomycin hydrochloride (vancomycin hydrochloride). Common drug interactions include biloma among females and disseminated intravascular coagulation among males.

The phase IV clinical study analyzes what interactions people have when they take Keytruda and Vancomycin hydrochloride. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Keytruda?

Keytruda has active ingredients of pembrolizumab. It is often used in renal cell carcinoma. eHealthMe is studying from 57,404 Keytruda users. Check the latest studies of Keytruda.

What is Vancomycin hydrochloride?

Vancomycin hydrochloride has active ingredients of vancomycin hydrochloride. It is often used in mrsa infection. eHealthMe is studying from 8,399 Vancomycin hydrochloride users. Check the latest studies of Vancomycin hydrochloride.

On Jul, 12, 2026

13 people who take Keytruda and Vancomycin hydrochloride together, and have interactions are studied.

Keytruda and Vancomycin hydrochloride drug interactions.

What are the common drug interactions of Keytruda and Vancomycin Hydrochloride, by gender? *:

female:

Biloma (extrabiliary collection of bile)
Malignant neoplasm progression (cancer tumour came back)
Tumour associated fever (fever because of tumour)
Febrile neutropenia (fever with reduced white blood cells)
Diarrhoea
Pyrexia (fever)
Rash
Rectal haemorrhage (bleeding from anus)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)

male:

Disseminated intravascular coagulation (systemic activation of blood coagulation)
Malignant neoplasm progression (cancer tumour came back)
Pyrexia (fever)
Small intestinal haemorrhage (bleeding from small intestine)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Hepatic enzyme increased
Nephritis (inflammation of the nephrons in the kidneys)
Urticaria (rash of round, red welts on the skin that itch intensely)
Adverse event
Bacterial infection

What are the common drug interactions of Keytruda and Vancomycin Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Febrile neutropenia (fever with reduced white blood cells)
Pyrexia (fever)
Rash

50-59:

Febrile neutropenia (fever with reduced white blood cells)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)

60+:

Disseminated intravascular coagulation (systemic activation of blood coagulation)
Bacterial infection
Pyrexia (fever)
Small intestinal haemorrhage (bleeding from small intestine)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Hepatic enzyme increased
Nephritis (inflammation of the nephrons in the kidneys)
Urticaria (rash of round, red welts on the skin that itch intensely)
Diarrhoea
Rectal haemorrhage (bleeding from anus)

What are the existing conditions these people have? *

Fever: 5 people, 38.46%
Type 2 Diabetes: 4 people, 30.77%
Lung Adenocarcinoma Stage Iv (the cancer has spread to other organs of the body, such as the other lung, brain, or liver): 4 people, 30.77%
Blood Beta-D-Glucan Increased: 4 people, 30.77%
Cancer Pain: 4 people, 30.77%
Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 4 people, 30.77%
Interstitial Lung Disease: 4 people, 30.77%
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low): 4 people, 30.77%
Pancreatitis (inflammation of pancreas): 3 people, 23.08%
Gastroenteritis Staphylococcal (inflammation of stomach and intestine caused by staphylococcal infection): 3 people, 23.08%

* Approximation only. Some reports may have incomplete information.

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