Klonopin and Folate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Klonopin (clonazepam) and Folate (folic acid). Common drug interactions include central nervous system lesion among females and malaise among males.

The phase IV clinical study analyzes what interactions people have when they take Klonopin and Folate. It is created by eHealthMe based on reports of 90 people who take the same drugs from the FDA, and is updated regularly.

What is Klonopin?

Klonopin has active ingredients of clonazepam. It is often used in stress and anxiety. eHealthMe is studying from 65,112 Klonopin users. Check the latest studies of Klonopin.

What is Folate?

Folate has active ingredients of folic acid. It is often used in rheumatoid arthritis. eHealthMe is studying from 6,546 Folate users. Check the latest studies of Folate.

On Jul, 11, 2026

90 people who take Klonopin and Folate together, and have interactions are studied.

What are the common drug interactions of Klonopin and Folate, by gender? *:

female:

Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Chest discomfort
Confusional state
Constipation
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cough
Delirium tremens (a psychotic condition typical of withdrawal in chronic alcoholics)
Diarrhoea
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dyspnoea (difficult or laboured respiration)

male:

Malaise (a feeling of general discomfort or uneasiness)
Nasopharyngitis (inflammation of the nasopharynx)
Attention deficit/hyperactivity disorder
Blood pressure increased
Bronchial secretion retention
Chest discomfort
Chronic kidney disease
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Delusion (a false belief or opinion)
Dementia with lewy bodies (progressive degenerative disease or syndrome of the brain)

What are the common drug interactions of Klonopin and Folate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

20-29:

Nasopharyngitis (inflammation of the nasopharynx)
Fatigue (feeling of tiredness)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Cardiac disorder
Cellulitis (infection under the skin)
Dehydration (dryness resulting from the removal of water)
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dyspnoea (difficult or laboured respiration)

30-39:

Attention deficit/hyperactivity disorder
Blood urine present
Dehydration (dryness resulting from the removal of water)
Depression
Disturbance in attention
Dysgeusia (disorder of the sense of taste)
Fatigue (feeling of tiredness)
Haemoglobin decreased
Infection
Localised oedema (fluid retention in a particular part of the body)

40-49:

Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Headache (pain in head)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Pain
Abdominal pain
Bipolar disorder (mood disorder)
Migraine (headache)
Neck pain
Palpitations (feelings or sensations that your heart is pounding or racing)

50-59:

Dysarthria (speech disorder)
Dysgraphia (impaired ability to learn to write)
Dyskinesia (abnormality or impairment of voluntary movement)
Electrocardiogram qt prolonged
Emotional disorder
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Finger deformity (a deformed position of the finger)
Flatulence (flatus expelled through the anus)
Gait disturbance

60+:

Fatigue (feeling of tiredness)
Dizziness
Asthenia (weakness)
Ataxia (loss of full control of bodily movements)
Attention deficit/hyperactivity disorder
Bipolar disorder (mood disorder)
Blood pressure increased
Bone disorder
Bronchial secretion retention
Cervical myelopathy (clinical syndrome characterized by clumsiness in hands; gait imbalance; caused by compression of the spinal cord)

What are the existing conditions these people have? *

Pain: 16 people, 17.78%
Fibromyalgia (a long-term condition which causes pain all over the body): 16 people, 17.78%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 13.33%
Depression: 10 people, 11.11%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 7.78%
Lyme Disease (a bacterial infection that is spread to humans by infected ticks): 7 people, 7.78%
High Blood Pressure: 7 people, 7.78%
High Blood Cholesterol: 7 people, 7.78%
Nausea (feeling of having an urge to vomit): 6 people, 6.67%
Headache (pain in head): 6 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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