Klonopin and Gemzar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Klonopin (clonazepam) and Gemzar (gemcitabine hydrochloride). Common drug interactions include nausea among females and cerebrovascular accident among males.

The phase IV clinical study analyzes what interactions people have when they take Klonopin and Gemzar. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Klonopin?

Klonopin has active ingredients of clonazepam. It is often used in stress and anxiety. eHealthMe is studying from 65,112 Klonopin users. Check the latest studies of Klonopin.

What is Gemzar?

Gemzar has active ingredients of gemcitabine hydrochloride. It is often used in pancreatic carcinoma. eHealthMe is studying from 20,315 Gemzar users. Check the latest studies of Gemzar.



On Aug, 04, 2026

39 people who take Klonopin and Gemzar together, and have interactions are studied.

Klonopin and Gemzar drug interactions.

What are the common drug interactions of Klonopin and Gemzar, by gender? *:

female:

  1. Nausea (feeling of having an urge to vomit)
  2. Ileus (a painful obstruction of the ileum or other part of the intestine)
  3. Jaw disorder (jaw disease)
  4. Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
  5. Pain
  6. Dyspnoea (difficult or laboured respiration)
  7. Atelectasis (partial or complete collapse of the lung)
  8. Osteonecrosis of jaw (death of bone of jaw)
  9. Renal cyst (kidney cyst)
  10. Constipation

male:

  1. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  2. Confusion
  3. Cough
  4. Dehydration (dryness resulting from the removal of water)
  5. Dysphagia (a condition in which swallowing is difficult or painful)
  6. Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
  7. Hypertension (high blood pressure)
  8. Speech disorder

What are the common drug interactions of Klonopin and Gemzar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Abdominal distension
  2. Anaemia (lack of blood)
  3. Arthralgia (joint pain)
  4. Atelectasis (partial or complete collapse of the lung)
  5. Back pain
  6. Confusional state
  7. Death
  8. Diarrhoea
  9. Dyspnoea (difficult or laboured respiration)
  10. Fall

20-29:

n/a

30-39:

  1. Headache (pain in head)
  2. Abdominal hernia
  3. Alopecia (absence of hair from areas of the body)
  4. Asthenia (weakness)
  5. Atelectasis (partial or complete collapse of the lung)
  6. Body temperature decreased
  7. Bone disorder
  8. Cellulitis (infection under the skin)
  9. Chest pain
  10. Chills (felling of cold)

40-49:

  1. Bone pain
  2. Erythema (redness of the skin)
  3. Osteomyelitis (infection of bone)
  4. Pain in jaw
  5. Pleural effusion (water on the lungs)
  6. Purulent discharge (discharge that contains pus)
  7. Upper respiratory tract infection
  8. Inflammation
  9. Pain
  10. Abdominal mass (localized enlargement or swelling in the human abdomen)

50-59:

  1. Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
  2. Hydronephrosis (water inside the kidney)
  3. Hyperlipidaemia (presence of excess lipids in the blood)
  4. Hypersensitivity
  5. Hypoaesthesia (reduced sense of touch or sensation)
  6. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
  7. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
  8. Immunodeficiency
  9. Incontinence (lack of moderation or self-control)
  10. Influenza

60+:

  1. Ascites (accumulation of fluid in the abdominal cavity)
  2. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  3. Thyroid neoplasm (tumour of thyroid)
  4. Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
  5. Hypertension (high blood pressure)
  6. Metastases to lymph nodes (cancer spreads to lymph node)
  7. Speech disorder
  8. Confusion
  9. Cough
  10. Dehydration (dryness resulting from the removal of water)

What are the existing conditions these people have? *

  1. Breast Cancer Metastatic: 18 people, 46.15%
  2. Breast Cancer: 18 people, 46.15%
  3. Depression: 15 people, 38.46%
  4. Pain: 9 people, 23.08%
  5. Metastases To Bone (cancer spreads to bone): 9 people, 23.08%
  6. Anaemia (lack of blood): 7 people, 17.95%
  7. Nausea (feeling of having an urge to vomit): 3 people, 7.69%
  8. Metastases To Bone Marrow (cancer spreads to bone marrow): 3 people, 7.69%
  9. Ovarian Cancer (cancer of ovary): 2 people, 5.13%
  10. Osteoporosis (bones weak and more likely to break): 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

Do you take Klonopin and Gemzar?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Klonopin and Gemzar:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Klonopin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Gemzar:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Klonopin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Gemzar and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on clonazepam and gemcitabine hydrochloride (the active ingredients of Klonopin and Gemzar, respectively), and Klonopin and Gemzar (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



Recent studies on eHealthMe: