Klonopin and Macitentan drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Klonopin and Macitentan. Common interactions include pneumonia among females.
The phase IV clinical study analyzes what interactions people who take Klonopin and Macitentan have. It is created by eHealthMe based on reports of 10 people who take Klonopin and Macitentan from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
10 people who take Klonopin and Macitentan together, and have interactions are studied.
What is Klonopin?
Klonopin has active ingredients of clonazepam. It is often used in stress and anxiety. eHealthMe is studying from 62,428 Klonopin users for its effectiveness, alternative drugs and more.
What is Macitentan?
Macitentan has active ingredients of macitentan. eHealthMe is studying from 6,358 Macitentan users for its effectiveness, alternative drugs and more.
Number of Klonopin and Macitentan reports submitted per year:

Common Klonopin and Macitentan drug interactions by gender *:
female:
- Pneumonia
- Blood pressure increased
- Cardiac failure congestive
- Cerebrovascular accident
- Chest pain
- Chronic obstructive pulmonary disease
- Dehydration
- Diarrhoea
- Disease progression
- Dysstasia
male:
n/a
Common Klonopin and Macitentan drug interactions by age *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
- Swelling
- Cardiac failure congestive
- Erythema
- Pain
- Pulmonary arterial hypertension
- Pyrexia
- Subcutaneous abscess
50-59:
- Abdominal pain
- Chest pain
- Dyspnoea
- Fatigue
- Fluid retention
- Nausea
- Oedema
- Oxygen saturation decreased
- Pleural effusion
- Pulmonary oedema
60+:
- Pneumonia
- Blood pressure increased
- Dysstasia
- Emphysema
- Enzyme abnormality
- Haemoglobin decreased
- Herpes zoster
- Influenza
- Influenza like illness
- Malaise
Common conditions people have *:
- Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 10 people, 100.00%
* Approximation only. Some reports may have incomplete information.
Do you take Klonopin and Macitentan?
Personalize this study to your gender and ageHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
- Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
- McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .
Related studies
Alternative drugs to, pros and cons of the 2 drugs:
- Klonopin (62,428 reports)
- Macitentan (6,358 reports)
Browse all drug interactions of Klonopin and Macitentan:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Klonopin side effects:
- Stress and anxiety: 5,458 reports
- Fatigue (feeling of tiredness): 4,937 reports
- Drug ineffective: 4,898 reports
- Depression: 4,404 reports
- Headache (pain in head): 4,220 reports
- Pain: 4,144 reports
- Insomnia (sleeplessness): 3,957 reports
Browse all side effects of Klonopin:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Macitentan side effects:
- Breathing difficulty: 1,014 reports
- Death: 744 reports
- Pneumonia: 585 reports
- Headache (pain in head): 475 reports
- Diarrhea: 399 reports
- Hypotension (abnormally low blood pressure): 385 reports
- Primary pulmonary hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 356 reports
- Fatigue (feeling of tiredness): 344 reports
- Fluid retention (an abnormal accumulation of fluid in the blood): 343 reports
Browse all side effects of Macitentan:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Klonopin interactions:
- Klonopin and Seroquel: 5,867 reports
- Klonopin and Neurontin: 4,829 reports
- Klonopin and Wellbutrin: 4,788 reports
- Klonopin and Cymbalta: 4,736 reports
- Klonopin and Zoloft: 4,700 reports
- Klonopin and Synthroid: 4,476 reports
- Klonopin and Aspirin: 4,295 reports
- Klonopin and Ambien: 4,100 reports
- Klonopin and Effexor: 4,029 reports
- Klonopin and Lamictal: 3,923 reports
Browse all interactions between Klonopin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Macitentan interactions:
- Macitentan and Adcirca: 888 reports
- Macitentan and Revatio: 517 reports
- Macitentan and Remodulin: 512 reports
- Macitentan and Selexipag: 511 reports
- Macitentan and Furosemide: 492 reports
- Macitentan and Tyvaso: 465 reports
- Macitentan and Adempas: 425 reports
- Macitentan and Tadalafil: 412 reports
- Macitentan and Spironolactone: 368 reports
- Macitentan and Coumadin: 311 reports
Browse all interactions between Macitentan and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on clonazepam and macitentan (the active ingredients of Klonopin and Macitentan, respectively), and Klonopin and Macitentan (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Klonopin and Macitentan.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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