Klonopin and Valacyclovir hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Klonopin (clonazepam) and Valacyclovir hydrochloride (valacyclovir hydrochloride). Common drug interactions include myalgia among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Klonopin and Valacyclovir hydrochloride. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Klonopin?

Klonopin has active ingredients of clonazepam. It is often used in stress and anxiety. eHealthMe is studying from 65,112 Klonopin users. Check the latest studies of Klonopin.

What is Valacyclovir hydrochloride?

Valacyclovir hydrochloride has active ingredients of valacyclovir hydrochloride. It is often used in herpes zoster. eHealthMe is studying from 12,929 Valacyclovir hydrochloride users. Check the latest studies of Valacyclovir hydrochloride.



On Jul, 07, 2026

40 people who take Klonopin and Valacyclovir hydrochloride together, and have interactions are studied.

Klonopin and Valacyclovir hydrochloride drug interactions.

What are the common drug interactions of Klonopin and Valacyclovir Hydrochloride, by gender? *:

female:

  1. Myalgia (muscle pain)
  2. Obesity (having too much body fat)
  3. Oropharyngeal pain
  4. Palpitations (feelings or sensations that your heart is pounding or racing)
  5. Pyrexia (fever)
  6. Rhinorrhoea (watery mucus discharge from the nose)
  7. Snoring
  8. Somnolence (a state of near-sleep, a strong desire for sleep)
  9. Suicidal ideation
  10. Temperature intolerance (inability to go in temperature)

male:

  1. Drug ineffective
  2. Fatigue (feeling of tiredness)
  3. Arthralgia (joint pain)
  4. Burning sensation
  5. Chest pain
  6. Cluster headache (one-sided head pain with tearing)
  7. Constipation
  8. Depression
  9. Dizziness
  10. Emotional distress

What are the common drug interactions of Klonopin and Valacyclovir Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Colitis microscopic (inflammation of colon with diarrhoea and abdominal cramps)
  2. Hyperhidrosis (abnormally increased sweating)
  3. Oral herpes (viral infection of mouth)

40-49:

  1. Dizziness
  2. Fall
  3. Folliculitis (infection of hair root)
  4. Head injury
  5. Headache (pain in head)
  6. Injection site reaction
  7. Insomnia (sleeplessness)
  8. Malaise (a feeling of general discomfort or uneasiness)
  9. Nasopharyngitis (inflammation of the nasopharynx)
  10. Odynophagia (painful swallowing, in the mouth (oropharynx) or oesophagus)

50-59:

  1. Drug ineffective
  2. Fatigue (feeling of tiredness)
  3. Dizziness
  4. Hypersomnia (excessive daytime sleepiness (eds))
  5. Lethargy (tiredness)
  6. Androgen deficiency
  7. Arthropathy
  8. Back pain
  9. Blood pressure decreased
  10. Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)

60+:

  1. Abdominal discomfort
  2. Drug hypersensitivity
  3. Hip fracture
  4. Hospitalisation
  5. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
  6. Intervertebral disc protrusion (spinal disc protrusion)
  7. Joint effusion (presence of extra fluid in joint covering)
  8. Jugular vein thrombosis (clot in jugular vein)
  9. Local swelling (swelling at the site of some application of substance or injury)
  10. Malaise (a feeling of general discomfort or uneasiness)

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 18 people, 45.00%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 27.50%
  3. Drowsiness: 10 people, 25.00%
  4. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 5 people, 12.50%
  5. Hiv Infection: 5 people, 12.50%
  6. Sleep Disorder: 4 people, 10.00%
  7. Depression: 4 people, 10.00%
  8. Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 10.00%
  9. Inflammation: 4 people, 10.00%
  10. High Blood Pressure: 4 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Klonopin and Valacyclovir hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Klonopin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Valacyclovir hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Klonopin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Valacyclovir hydrochloride and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on clonazepam and valacyclovir hydrochloride (the active ingredients of Klonopin and Valacyclovir hydrochloride, respectively), and Klonopin and Valacyclovir hydrochloride (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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