Konakion and Cotrim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Konakion (phytonadione) and Cotrim (sulfamethoxazole; trimethoprim). Common drug interactions include pain in limb among females and multi-organ failure among males.

The phase IV clinical study analyzes what interactions people have when they take Konakion and Cotrim. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Konakion?

Konakion has active ingredients of phytonadione. eHealthMe is studying from 1,342 Konakion users. Check the latest studies of Konakion.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

On Jul, 16, 2026

35 people who take Konakion and Cotrim together, and have interactions are studied.

What are the common drug interactions of Konakion and Cotrim, by gender? *:

female:

Pain in limb
Nausea (feeling of having an urge to vomit)
Angiopathy (generic term for a disease of the blood vessels)
Brain death
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Circulatory collapse
Hypoxic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)
Oesophageal varices haemorrhage (bleeding from extremely dilated sub-mucosal veins in the lower third of the oesophagus)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pleural effusion (water on the lungs)

male:

Multi-organ failure (multisystem organ failure)
Hepatic failure (liver failure)
Cholangitis (infection of the bile duct)
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Critical illness polyneuropathy
Dyspnoea (difficult or laboured respiration)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)

What are the common drug interactions of Konakion and Cotrim, by age (0-1 to 60+)? *:

0-1:

Acute circulatory failure (shock)
Angioneurotic oedema (swelling that occurs just beneath the surface of the skin or mucous membranes)
Ascites (accumulation of fluid in the abdominal cavity)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins)
Mucosal haemorrhage (bleeding from mucous membrane)
Oedema (fluid collection in tissue)
Pyrexia (fever)
Skin ulcer

2-9:

Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haemorrhage (bleeding)
Mucosal erosion (peeling off of mucous membrane)
Mucosal inflammation (infection of mucous membrane)
Skin ulcer
Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Upper respiratory tract infection

10-19:

Hypoaesthesia (reduced sense of touch or sensation)
Pain in limb
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Paresis (a condition of muscular weakness)
Diplegia (paralysis of corresponding parts on both sides of the body)
Monoparesis (one limb is very weak, but not completely paralyzed)

20-29:

n/a

30-39:

Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Angiopathy (generic term for a disease of the blood vessels)
Sepsis (a severe blood infection that can lead to organ failure and death)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)

40-49:

Conjunctivitis (pink eye)
Epidermal necrolysis (skin condition that is usually caused by a reaction to drugs)
Multi-organ failure (multisystem organ failure)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Erythema (redness of the skin)
Hypersensitivity
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Oedema (fluid collection in tissue)
Oral mucosal eruption (a sudden appearing of rash on mucous membrane of mouth)
Pyrexia (fever)

50-59:

Lung disorder (lung disease)
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Myocardial fibrosis (a condition in which the heart's muscle cells are impaired)
Nasal disorder (diseases of nose)
Nephrosclerosis (hardening of the kidney due to renovascular disease)
Oedema peripheral (superficial swelling)
Oesophagitis ulcerative (inflammation of oesophagus with multiple ulcers)
Operative haemorrhage (bleeding due to surgery)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

60+:

Cystitis (inflammation of the wall of the bladder)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Abdominal pain
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Balance disorder
Constipation
Exercise tolerance decreased
Right ventricular failure (right half of the heart fails to work)
Syncope (loss of consciousness with an inability to maintain postural tone)
Inappropriate antidiuretic hormone secretion

What are the existing conditions these people have? *

Pain: 7 people, 20.00%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 5 people, 14.29%
Gastritis (inflammation of stomach): 5 people, 14.29%
Oedema (fluid collection in tissue): 4 people, 11.43%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 4 people, 11.43%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 3 people, 8.57%
High Blood Pressure: 3 people, 8.57%
Constipation: 3 people, 8.57%
Infection: 3 people, 8.57%
Fever: 3 people, 8.57%

* Approximation only. Some reports may have incomplete information.

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