Koselugo and Zofran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Koselugo (selumetinib sulfate) and Zofran (ondansetron hydrochloride). Common drug interactions include fatigue among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Koselugo and Zofran. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Koselugo?

Koselugo has active ingredients of selumetinib sulfate. eHealthMe is studying from 431 Koselugo users. Check the latest studies of Koselugo.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

On Jul, 15, 2026

26 people who take Koselugo and Zofran together, and have interactions are studied.

What are the common drug interactions of Koselugo and Zofran, by gender? *:

female:

Fatigue (feeling of tiredness)
Drug hypersensitivity
Drug ineffective
Neoplasm (tumour)
Asthenia (weakness)
Headache (pain in head)
Hydrocephalus (water on the brain)
Muscular weakness (muscle weakness)
Neoplasm progression (growth of tumour)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

male:

Death
Diarrhoea
Influenza
Large intestinal obstruction
Pain
Pneumonia
Pyrexia (fever)
Respiratory failure (inadequate gas exchange by the respiratory system)
Somnolence (a state of near-sleep, a strong desire for sleep)
Thrombosis (formation of a blood clot inside a blood vessel)

What are the common drug interactions of Koselugo and Zofran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Feeding disorder (when children refuse to eat certain food groups)
Influenza
Pneumonia
Somnolence (a state of near-sleep, a strong desire for sleep)
Tympanic membrane perforation (a break in continuity of ear drum)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Asthenia (weakness)
Blood creatine phosphokinase increased
Fatigue (feeling of tiredness)
Headache (pain in head)

10-19:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Abdominal discomfort
Acne (skin problems that cause pimples)
Alopecia (absence of hair from areas of the body)
Blood pressure increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Diarrhoea
Dysarthria (speech disorder)
Haematochezia (passage of stools containing blood)
Hemiplegia (paralysis of one side of the body)

20-29:

Death
Rash
Stomatitis (inflammation of mucous membrane of mouth)

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Nervous System Neoplasm Benign (non cancer forming tumour of nervous system): 4 people, 15.38%
Brain Neoplasm Malignant (brain cancer tumour): 3 people, 11.54%

* Approximation only. Some reports may have incomplete information.

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