Krystexxa and Medrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Krystexxa (pegloticase) and Medrol (methylprednisolone). Common drug interactions include gout among females and cellulitis among males.

The phase IV clinical study analyzes what interactions people have when they take Krystexxa and Medrol. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Krystexxa?

Krystexxa has active ingredients of pegloticase. eHealthMe is studying from 2,548 Krystexxa users. Check the latest studies of Krystexxa.

What is Medrol?

Medrol has active ingredients of methylprednisolone. It is often used in rheumatoid arthritis. eHealthMe is studying from 24,443 Medrol users. Check the latest studies of Medrol.

On Jul, 05, 2026

16 people who take Krystexxa and Medrol together, and have interactions are studied.

What are the common drug interactions of Krystexxa and Medrol, by gender? *:

female:

Gout (uric acid crystals building up in the body)
Infusion related reaction
Rash

male:

Cellulitis (infection under the skin)
Hypertension (high blood pressure)
Diarrhoea
Embolic stroke (stroke due to obstruction due to an embolus)
Flushing (the warm, red condition of human skin)
Infusion related reaction
Pruritus (severe itching of the skin)
Salivary hypersecretion (excess saliva secretion)
Sleep disorder
Therapeutic response decreased (less preventive response)

What are the common drug interactions of Krystexxa and Medrol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood uric acid increased
Chest pain
Gout (uric acid crystals building up in the body)
Infusion related reaction

40-49:

Infusion related reaction
Rash
Death
Abdominal discomfort
Diarrhoea
Gout (uric acid crystals building up in the body)
Salivary hypersecretion (excess saliva secretion)
Therapeutic response decreased (less preventive response)
Tremor (trembling or shaking movements in one or more parts of your body)

50-59:

n/a

60+:

Cellulitis (infection under the skin)
Hypertension (high blood pressure)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Gout (uric acid crystals building up in the body)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Cough
Embolic stroke (stroke due to obstruction due to an embolus)
Flushing (the warm, red condition of human skin)
Pruritus (severe itching of the skin)
Sleep disorder

What are the existing conditions these people have? *

Gout (uric acid crystals building up in the body): 10 people, 62.50%
Gouty Tophus (a deposit of urates in the skin and tissue around a joint or in the external ear): 4 people, 25.00%
Allergies: 2 people, 12.50%
Zinc Deficiency: 1 person, 6.25%
Seasonal Allergy (allergic condition due to certain season): 1 person, 6.25%
Pain: 1 person, 6.25%
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract): 1 person, 6.25%
Joint Pain: 1 person, 6.25%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 1 person, 6.25%
High Blood Pressure: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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