Kyprolis and Akynzeo drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Kyprolis (carfilzomib) and Akynzeo (netupitant; palonosetron hydrochloride). Common drug interactions include dyspnoea among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Kyprolis and Akynzeo. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Kyprolis?

Kyprolis has active ingredients of carfilzomib. It is often used in multiple myeloma. eHealthMe is studying from 15,080 Kyprolis users. Check the latest studies of Kyprolis.

What is Akynzeo?

Akynzeo has active ingredients of netupitant; palonosetron hydrochloride. eHealthMe is studying from 1,332 Akynzeo users. Check the latest studies of Akynzeo.



On Apr, 11, 2026

16 people who take Kyprolis and Akynzeo together, and have interactions are studied.

Kyprolis and Akynzeo drug interactions.

What are the common drug interactions of Kyprolis and Akynzeo, by gender? *:

female:

  1. Dyspnoea (difficult or laboured respiration)
  2. Fatigue (feeling of tiredness)
  3. Hypokalaemia (low potassium)
  4. Malaise (a feeling of general discomfort or uneasiness)
  5. Nausea (feeling of having an urge to vomit)
  6. Neuropathy peripheral (surface nerve damage)
  7. Pyrexia (fever)
  8. Thrombocytopenia (decrease of platelets in blood)
  9. Diarrhoea
  10. Asthenia (weakness)

male:

  1. Abdominal pain
  2. Headache (pain in head)
  3. Nausea (feeling of having an urge to vomit)
  4. Pyrexia (fever)

What are the common drug interactions of Kyprolis and Akynzeo, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Nausea (feeling of having an urge to vomit)

50-59:

  1. Arthralgia (joint pain)
  2. Asthenia (weakness)
  3. Bone pain
  4. Diarrhoea
  5. Hypokalaemia (low potassium)
  6. Nausea (feeling of having an urge to vomit)
  7. Neuropathy peripheral (surface nerve damage)
  8. Pyrexia (fever)

60+:

  1. Thrombocytopenia (decrease of platelets in blood)
  2. Diarrhoea
  3. Abdominal pain
  4. Asthenia (weakness)
  5. Drug ineffective
  6. Dyspnoea (difficult or laboured respiration)
  7. Fatigue (feeling of tiredness)
  8. Headache (pain in head)
  9. Malaise (a feeling of general discomfort or uneasiness)
  10. Pyrexia (fever)

* Approximation only. Some reports may have incomplete information.

Do you take Kyprolis and Akynzeo?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Kyprolis and Akynzeo:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Kyprolis:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Akynzeo:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Kyprolis and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Akynzeo and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on carfilzomib and netupitant; palonosetron hydrochloride (the active ingredients of Kyprolis and Akynzeo, respectively), and Kyprolis and Akynzeo (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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