Kytril and Maxzide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Kytril (granisetron hydrochloride) and Maxzide (hydrochlorothiazide; triamterene). Common drug interactions include heart rate increased among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Kytril and Maxzide. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Kytril?

Kytril has active ingredients of granisetron hydrochloride. eHealthMe is studying from 10,766 Kytril users. Check the latest studies of Kytril.

What is Maxzide?

Maxzide has active ingredients of hydrochlorothiazide; triamterene. It is often used in high blood pressure. eHealthMe is studying from 9,152 Maxzide users. Check the latest studies of Maxzide.

On Jul, 11, 2026

26 people who take Kytril and Maxzide together, and have interactions are studied.

What are the common drug interactions of Kytril and Maxzide, by gender? *:

female:

Heart rate increased
Hypersensitivity
Incision site complication
Injury
Insomnia (sleeplessness)
Intestinal obstruction
Laryngitis (inflammation of the larynx)
Lethargy (tiredness)
Limb discomfort (discomfort in leg)
Local swelling (swelling at the site of some application of substance or injury)

male:

Nausea (feeling of having an urge to vomit)
Alopecia (absence of hair from areas of the body)
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Epistaxis (bleed from the nose)
Haematuria (presence of blood in urine)
Herpes zoster
Hypoaesthesia (reduced sense of touch or sensation)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)

What are the common drug interactions of Kytril and Maxzide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cough
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Pericardial effusion (fluid around the heart)
Pleural effusion (water on the lungs)
Rash erythematous (redness of the skin)
Tenderness (pain or discomfort when an affected area is touched)

50-59:

Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)
Dizziness
Dizziness postural
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Heart rate increased

60+:

Breast cancer metastatic
Hepatic failure (liver failure)
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)
Diarrhoea
Epistaxis (bleed from the nose)
General physical health deterioration (weak health status)
Haematuria (presence of blood in urine)
Herpes zoster
Hypoaesthesia (reduced sense of touch or sensation)
Impaired healing

What are the existing conditions these people have? *

Pain: 4 people, 15.38%
Ovarian Cancer (cancer of ovary): 4 people, 15.38%
High Blood Cholesterol: 3 people, 11.54%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 11.54%
Asthma: 3 people, 11.54%
Breast Cancer Metastatic: 3 people, 11.54%
Constipation: 3 people, 11.54%
Depression: 3 people, 11.54%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 3 people, 11.54%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 11.54%

* Approximation only. Some reports may have incomplete information.

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